Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.63 |
| ▸ | HTR5A | P47898 | 1/20 | 0.63 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.63 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.63 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.61 |
| ▸ | HTR2A | P28223 | 1/20 | 0.56 |
| ▸ | HTR2C | P28335 | 1/20 | 0.56 |
| ▸ | PARP1 | P09874 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | TNKS | O95271 | 1/20 | 0.47 |
| ▸ | GPR3 | P46089 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25911476 | 0.79 | HSD17B10 (0.61) | KDM4EPARP1MEN1KMT2ACYP1A2 | |
| SCHEMBL30158836 | 0.79 | HSD17B10 (0.61) | KDM4EPARP1MEN1KMT2ACYP1A2 | |
| SCHEMBL4668622 | 0.79 | MEN1 (0.66) | KDM4EPARP1MEN1KMT2ACYP1A2 | |
| SCHEMBL30273084 | 0.79 | MEN1 (0.66) | KDM4EPARP1MEN1KMT2ACYP1A2 | |
| SCHEMBL31164689 | 0.78 | PARP1 (0.51) | NISCHPARP1MEN1KMT2ACYP1A2 | |
| Tryptoline SCHEMBL171755 | 0.77 | NISCH (1.00) | KDM4EHTR5ANISCHNR2E1TAAR1 | |
| SCHEMBL169954 | 0.77 | TAAR1 (0.96) | KDM4EHTR5ANISCHNR2E1TAAR1 | |
| Tryptoline SCHEMBL12190178 | 0.77 | NISCH (1.00) | KDM4EHTR5ANISCHNR2E1TAAR1 | |
| Tryptoline SCHEMBL29350043 | 0.77 | NISCH (1.00) | KDM4EHTR5ANISCHNR2E1TAAR1 | |
| Hydrochloric Acid SCHEMBL30293232 | 0.77 | MEN1 (0.64) | KDM4EPARP1MEN1KMT2ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9255096-B1 | Substituted 1,2,3,4-tetrahydrobenzo[C][2,7] naphthyridines and derivatives thereof as kinase inhibitors | ALLERGAN, INC. (US) | 2016-02-09 | — | — | US | disclosed |
| US-9255096-B1 | Substituted 1,2,3,4-tetrahydrobenzo[C][2,7] naphthyridines and derivatives thereof as kinase inhibitors | ALLERGAN, INC. (US) | 2016-02-09 | — | — | US | disclosed |
| EP-1714961-B1 | INDAZOLE COMPOUND AND PHARMACEUTICAL USE THEREOF | MITSUBISHI TANABE PHARMA CORP (JP) | 2015-12-09 | — | — | EP | disclosed |
| US-7994196-B2 | Indazole compound and pharmaceutical use thereof | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2011-08-09 | — | — | US | disclosed |
| US-20070173537-A1 | Indazole compound and pharmaceutical use thereof | MITSUBISHI PHARMA CORPORATION (JP) | 2007-07-26 | — | — | US | disclosed |
| EP-1714961-A1 | INDAZOLE COMPOUND AND PHARMACEUTICAL USE THEREOF | Mitsubishi Pharma Corporation (JP) | 2006-10-25 | — | — | EP | disclosed |
| US-3991064-A | Benzonaphthyridines | WARNER-LAMBERT COMPANY (US) | 1976-11-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070173537-A1 | Indazole compound and pharmaceutical use thereof | CYP3A5, CYP3A43, TP53 | KDM4E 2565/4885HTR5A 1270/4885NISCH 1131/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.