Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 20/20 | 1.00 |
| ▸ | MKNK2 | Q9HBH9 | 20/20 | 1.00 |
| ▸ | EIF4E | P06730 | 15/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 6/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22697341 | 0.91 | MKNK1 (0.84) | MKNK1MKNK2EIF4EKCNH2 | |
| SCHEMBL22697335 | 0.90 | MKNK1 (0.98) | MKNK1MKNK2EIF4EKCNH2 | |
| SCHEMBL22697090 | 0.90 | MKNK1 (1.00) | MKNK1MKNK2EIF4EKCNH2 | |
| SCHEMBL22697092 | 0.90 | MKNK1 (1.00) | MKNK1MKNK2EIF4EKCNH2 | |
| SCHEMBL22697278 | 0.90 | MKNK1 (1.00) | MKNK1MKNK2EIF4EKCNH2 | |
| SCHEMBL22697276 | 0.89 | MKNK1 (1.00) | MKNK1MKNK2EIF4EKCNH2 | |
| Hydrochloric Acid SCHEMBL30045666 | 0.89 | MKNK1 (0.98) | MKNK1MKNK2EIF4EKCNH2 | |
| SCHEMBL22697289 | 0.89 | MKNK1 (1.00) | MKNK1MKNK2EIF4EKCNH2 | |
| SCHEMBL22697152 | 0.89 | MKNK1 (1.00) | MKNK1MKNK2EIF4EKCNH2 | |
| SCHEMBL22697346 | 0.88 | MKNK1 (1.00) | MKNK1MKNK2EIF4EKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111978325-B | Imidazopyridazine MNK1/MNK2 kinase inhibitor, and preparation method and application thereof | 中国药科大学 | 2023-11-17 | — | — | CN | disclosed |
| WO-2020233716-A1 | IMIDAZOPYRIDAZINE MNK1/MNK2 KINASE INHIBITORS, PREPARATION METHOD THEREFOR AND USE THEREOF | 上海道熵生物科技有限公司 (CN) | 2020-11-26 | — | — | WO | disclosed |