Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 16/20 | 0.90 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.90 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.90 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.90 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.90 |
| ▸ | FLT3 | P36888 | 1/20 | 0.90 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.90 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.90 |
| ▸ | KIT | P10721 | 3/20 | 0.71 |
| ▸ | KDR | P35968 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Olverembatinib SCHEMBL29387193 | 0.95 | ABL1 (1.00) | ABL1FGFR1CYP2C9PDGFRACYP2C19 | |
| Olverembatinib SCHEMBL3424528 | 0.95 | ABL1 (1.00) | ABL1FGFR1CYP2C9PDGFRACYP2C19 | |
| Olverembatinib SCHEMBL29514988 | 0.95 | ABL1 (1.00) | ABL1FGFR1CYP2C9PDGFRACYP2C19 | |
| Olverembatinib SCHEMBL30456095 | 0.94 | ABL1 (0.99) | ABL1FGFR1CYP2C9PDGFRACYP2C19 | |
| Olverembatinib SCHEMBL29515011 | 0.94 | ABL1 (0.99) | ABL1FGFR1CYP2C9PDGFRACYP2C19 | |
| SCHEMBL26910782 | 0.94 | ABL1 (0.88) | ABL1FGFR1CYP2C9PDGFRACYP2C19 | |
| Olverembatinib SCHEMBL14953130 | 0.94 | ABL1 (0.99) | ABL1FGFR1CYP2C9PDGFRACYP2C19 | |
| SCHEMBL24340587 | 0.94 | ABL1 (0.89) | ABL1FGFR1CYP2C9PDGFRACYP2C19 | |
| Olverembatinib SCHEMBL29652687 | 0.92 | ABL1 (0.94) | ABL1FGFR1CYP2C9PDGFRACYP2C19 | |
| Olverembatinib SCHEMBL14953403 | 0.92 | ABL1 (0.94) | ABL1FGFR1CYP2C9PDGFRACYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3741751-A1 | HETEROCYCLIC ALKYNYL BENZENE COMPOUNDS AND MEDICAL COMPOSITIONS AND USES THEREOF | Guangzhou Healthquest Pharma Co., Ltd. (CN) | 2020-11-25 | — | — | EP | disclosed |