Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 18/20 | 0.55 |
| ▸ | TDO2 | P48775 | 15/20 | 0.55 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18137443 | 0.83 | IDO1 (0.68) | IDO1TDO2 | |
| SCHEMBL22701465 | 0.76 | IDO1 (0.65) | IDO1TDO2 | |
| SCHEMBL19951158 | 0.75 | IDO1 (0.71) | IDO1TDO2 | |
| SCHEMBL18137487 | 0.75 | IDO1 (0.71) | IDO1TDO2 | |
| SCHEMBL19951072 | 0.75 | IDO1 (0.71) | IDO1TDO2 | |
| SCHEMBL18137360 | 0.73 | IDO1 (0.51) | IDO1TDO2 | |
| SCHEMBL18137365 | 0.72 | IDO1 (0.49) | IDO1TDO2 | |
| SCHEMBL18132284 | 0.71 | IDO1 (0.72) | IDO1TDO2 | |
| SCHEMBL18132278 | 0.71 | IDO1 (1.00) | IDO1TDO2 | |
| SCHEMBL18132210 | 0.71 | IDO1 (1.00) | IDO1TDO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3280715-B1 | NOVEL 5 OR 8-SUBSTITUTED IMIDAZO [1, 5-a]PYRIDINES AS INDOLEAMINE AND/OR TRYPTOPHANE 2, 3-DIOXYGENASES | BEIGENE LTD (KY) | 2020-11-25 | — | — | EP | disclosed |