Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 18/20 | 0.53 |
| ▸ | PIK3CB | P42338 | 15/20 | 0.53 |
| ▸ | PIK3CA | P42336 | 11/20 | 0.53 |
| ▸ | PIK3CG | P48736 | 9/20 | 0.53 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2270479 | 0.90 | PIK3CD (0.50) | PIK3CDPIK3CBPIK3CAPIK3CGPIK3R1 | |
| SCHEMBL2272961 | 0.87 | PIK3CD (0.50) | PIK3CDPIK3CBPIK3CAPIK3CG | |
| SCHEMBL2274271 | 0.86 | PIK3CD (0.57) | PIK3CDPIK3CBPIK3CAPIK3CGPIK3R1 | |
| SCHEMBL2274919 | 0.82 | PIK3CB (0.63) | PIK3CDPIK3CBPIK3CAPIK3CGPIK3R1 | |
| SCHEMBL2276341 | 0.82 | PIK3CD (0.53) | PIK3CDPIK3CBPIK3CAPIK3CGPIK3R1 | |
| SCHEMBL2276337 | 0.82 | PIK3CD (0.53) | PIK3CDPIK3CBPIK3CAPIK3CGPIK3R1 | |
| SCHEMBL2273010 | 0.79 | PIK3CD (0.58) | PIK3CDPIK3CBPIK3CAPIK3CGPIK3R1 | |
| SCHEMBL2674040 | 0.77 | PIK3CD (0.70) | PIK3CDPIK3CBPIK3CAPIK3CG | |
| SCHEMBL2673176 | 0.77 | PIK3CD (0.68) | PIK3CDPIK3CBPIK3CAPIK3CG | |
| SCHEMBL2272728 | 0.77 | PIK3CD (0.75) | PIK3CDPIK3CBPIK3CAPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8563540-B2 | Pyrido[3,2-d]pyrimidine PI3K delta inhibitor compounds and methods of use | GENENTECH, INC. (US) | 2013-10-22 | — | — | US | disclosed |
| US-20130225557-A1 | PYRIDO[3,2-d]PYRIMIDINE PI3K DELTA INHIBITOR COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2013-08-29 | — | — | US | disclosed |
| US-8440651-B2 | Pyrido[3,2-d]pyrimidine PI3K delta inhibitor compounds and methods of use | F. HOFFMANN-LA ROCHE AG (CH) | 2013-05-14 | — | — | US | disclosed |
| US-20110207713-A1 | PYRIDO[3,2-d]PYRIMIDINE PI3K DELTA INHIBITOR COMPOUNDS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2011-08-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130225557-A1 | PYRIDO[3,2-d]PYRIMIDINE PI3K DELTA INHIBITOR COMPOUNDS AND METHODS OF USE | PIK3CA, PIK3CD, PIK3CB | PIK3CD 2/4885PIK3CB 3/4885PIK3CA 1/4885 |
| US-20110207713-A1 | PYRIDO[3,2-d]PYRIMIDINE PI3K DELTA INHIBITOR COMPOUNDS AND METHODS OF USE | PIK3CA, PIK3CD, PIK3CB | PIK3CD 2/4885PIK3CB 3/4885PIK3CA 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.