Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 3/20 | 0.69 |
| ▸ | APP | P05067 | 8/20 | 0.67 |
| ▸ | NPC1 | O15118 | 2/20 | 0.59 |
| ▸ | RAB9A | P51151 | 2/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | RXRA | P19793 | 1/20 | 0.59 |
| ▸ | RXRB | P28702 | 1/20 | 0.59 |
| ▸ | CA12 | O43570 | 1/20 | 0.57 |
| ▸ | CA1 | P00915 | 1/20 | 0.57 |
| ▸ | CA2 | P00918 | 1/20 | 0.57 |
| ▸ | CA7 | P43166 | 1/20 | 0.57 |
| ▸ | CA9 | Q16790 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18429678 | 1.00 | MAOB (0.69) | MAOBAPPNPC1RAB9APOLB | |
| SCHEMBL20000873 | 0.89 | APP (0.80) | MAOBAPPNPC1RAB9APOLB | |
| SCHEMBL2399080 | 0.89 | APP (0.80) | MAOBAPPRXRARXRBCA12 | |
| SCHEMBL1310325 | 0.86 | KMT2A (0.58) | MAOBAPPNPC1RAB9ACA1 | |
| SCHEMBL310367 | 0.85 | MAOB (0.60) | MAOBAPPNPC1RAB9APOLB | |
| SCHEMBL14154468 | 0.84 | APP (0.67) | MAOBAPPRXRARXRBCA12 | |
| SCHEMBL8960543 | 0.84 | APP (0.67) | MAOBAPPNPC1RAB9APOLB | |
| SCHEMBL13929696 | 0.84 | APP (0.67) | MAOBAPPNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL171857 | 0.82 | APP (0.69) | MAOBAPPNPC1RAB9APOLB | |
| SCHEMBL3618116 | 0.82 | APP (0.69) | MAOBAPPRXRARXRBCA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022263676-A1 | POLYSUBSTITUTED 4-HYDROXYPYRIDINE AND 4-HYDROXYQUINOLINE DERIVATIVES AS GPR84 ANTAGONISTS | UNIVERSITY OF COPENHAGEN (DK) | 2022-12-22 | — | — | WO | disclosed |
| EP-3581565-A1 | PHENYL BENZYL ETHER DERIVATIVE AND PREPARATION METHOD AND APPLICATION THEREOF | Beijing Zhibo Bio-Medical Technology Co., Ltd. (CN) | 2019-12-18 | — | — | EP | disclosed |
| US-20170037008-A1 | PHENYL BENZYL ETHER DERIVATIVE AND PREPARATION METHOD AND APPLICATION THEREOF | ZHANG ZHIYONG (CN) | 2017-02-09 | — | — | US | disclosed |
| CN-103724207-B | Phenylbenzyl ether derivative and its preparation method and application | 北京智博高科生物技术有限公司 | 2016-07-06 | — | — | CN | disclosed |
| CN-105520941-A | Substituted gamma lactams as therapeutic agents | ALLERGAN INC | 2016-04-27 | — | — | CN | disclosed |
| EP-2139331-B1 | COMPOSITIONS AND METHODS RELATING TO NOVEL COMPOUNDS AND TARGETS THEREOF | UNIV MICHIGAN (US) | 2013-02-20 | — | — | EP | disclosed |
| EP-2139331-B1 | COMPOSITIONS AND METHODS RELATING TO NOVEL COMPOUNDS AND TARGETS THEREOF | UNIV MICHIGAN (US) | 2013-02-20 | — | — | EP | disclosed |
| US-20120289498-A1 | Compositions And Methods Relating To Novel Compounds And Targets Thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2012-11-15 | — | — | US | disclosed |
| US-20120289498-A1 | Compositions And Methods Relating To Novel Compounds And Targets Thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2012-11-15 | — | — | US | disclosed |
| US-20120289498-A1 | Compositions And Methods Relating To Novel Compounds And Targets Thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2012-11-15 | — | — | US | disclosed |
| US-7851465-B2 | Compositions and methods relating to novel compounds and targets thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2010-12-14 | — | — | US | disclosed |
| US-7851465-B2 | Compositions and methods relating to novel compounds and targets thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2010-12-14 | — | — | US | disclosed |
| US-7851465-B2 | Compositions and methods relating to novel compounds and targets thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2010-12-14 | — | — | US | disclosed |
| EP-2139331-A1 | COMPOSITIONS AND METHODS RELATING TO NOVEL COMPOUNDS AND TARGETS THEREOF | The Regents of the University of Michigan (US) | 2010-01-06 | — | — | EP | disclosed |
| US-20080269194-A1 | Compositions And Methods Relating To Novel Compounds And Targets Thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2008-10-30 | — | — | US | disclosed |
| US-20080269194-A1 | Compositions And Methods Relating To Novel Compounds And Targets Thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2008-10-30 | — | — | US | disclosed |
| US-20080269194-A1 | Compositions And Methods Relating To Novel Compounds And Targets Thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2008-10-30 | — | — | US | disclosed |
| WO-2008112553-A1 | COMPOSITIONS AND METHODS RELATING TO NOVEL COMPOUNDS AND TARGETS THEREOF | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2008-09-18 | — | — | WO | disclosed |
| WO-2008112553-A1 | COMPOSITIONS AND METHODS RELATING TO NOVEL COMPOUNDS AND TARGETS THEREOF | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2008-09-18 | — | — | WO | disclosed |
| WO-1994010179-A1 | ARYLBORON ACIDS AS INTERMEDIATES IN THE PRODUCTION OF COMPONENTS OF LIQUID-CRYSTAL MIXTURES | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-05-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170037008-A1 | PHENYL BENZYL ETHER DERIVATIVE AND PREPARATION METHOD AND APPLICATION THEREOF | APP, PSEN1, PSEN2 | MAOB 264/4885APP 1/4885NPC1 69/4885 |
| US-20080269194-A1 | Compositions And Methods Relating To Novel Compounds And Targets Thereof | BAX, BAD, BAK1 | MAOB 1055/4885APP 1104/4885NPC1 1862/4885 |
| US-20120289498-A1 | Compositions And Methods Relating To Novel Compounds And Targets Thereof | BAX, BAD, BAK1 | MAOB 1055/4885APP 1104/4885NPC1 1862/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.