Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 6/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | TNKS | O95271 | 4/20 | 0.36 |
| ▸ | TNKS2 | Q9H2K2 | 4/20 | 0.36 |
| ▸ | XDH | P47989 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | MMP13 | P45452 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30067618 | 0.94 | MEN1 (0.39) | MEN1KMT2AHPGDLMNATNKS | |
| SCHEMBL24483751 | 0.94 | MEN1 (0.39) | MEN1KMT2AHPGDLMNATNKS | |
| SCHEMBL24483074 | 0.93 | MEN1 (0.41) | MEN1KMT2AHPGDLMNATNKS | |
| SCHEMBL30067501 | 0.89 | MEN1 (0.39) | MEN1KMT2AHPGDLMNATNKS | |
| SCHEMBL24483735 | 0.86 | MEN1 (0.40) | MEN1KMT2AHPGDLMNATNKS | |
| SCHEMBL24483080 | 0.85 | HPGD (0.42) | MEN1KMT2AHPGDLMNATSHR | |
| SCHEMBL30067299 | 0.85 | HPGD (0.42) | MEN1KMT2AHPGDLMNATSHR | |
| SCHEMBL30067702 | 0.84 | MEN1 (0.39) | MEN1KMT2AHPGDLMNATNKS | |
| SCHEMBL30067270 | 0.84 | HPGD (0.41) | MEN1KMT2AHPGDLMNATNKS | |
| SCHEMBL30067435 | 0.84 | TP53 (0.41) | MEN1KMT2AHPGDLMNATNKS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022240971-A2 | KRAS G12D INHIBITORS AND USES THEREOF | 1200 PHARMA LLC (US) | 2022-11-17 | — | — | WO | disclosed |
| WO-2022115439-A1 | KRAS G12C INHIBITORS AND USES THEREOF | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2022-06-02 | — | — | WO | disclosed |
| WO-2020236940-A1 | KRAS G12C INHIBITORS AND USES THEREOF | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2020-11-26 | — | — | WO | disclosed |