Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ADH1B | P00325 | 1/20 | 0.36 |
| ▸ | ADH1C | P00326 | 1/20 | 0.36 |
| ▸ | ADH1A | P07327 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16665070 | 0.78 | TDP1 (0.35) | TDP1ADH1BADH1CADH1A | |
| SCHEMBL22652868 | 0.77 | TDP1 (0.39) | TDP1 | |
| SCHEMBL11484246 | 0.76 | TDP1 (0.33) | TDP1ADH1BADH1CADH1A | |
| SCHEMBL1676713 | 0.73 | — | — | |
| SCHEMBL6852728 | 0.73 | — | — | |
| SCHEMBL5695546 | 0.73 | — | — | |
| SCHEMBL8757885 | 0.71 | — | — | |
| SCHEMBL13076518 | 0.71 | — | — | |
| SCHEMBL13859875 | 0.71 | — | — | |
| SCHEMBL15896621 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020236825-A2 | MCL-1 INHIBITOR ANTIBODY-DRUG CONJUGATES AND METHODS OF USE | NOVARTIS AG (CH) | 2020-11-26 | — | — | WO | disclosed |