Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 18/20 | 0.50 |
| ▸ | JAK2 | O60674 | 14/20 | 0.50 |
| ▸ | TYK2 | P29597 | 10/20 | 0.50 |
| ▸ | JAK3 | P52333 | 10/20 | 0.50 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | PRKCA | P17252 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2363705 | 0.87 | JAK1 (0.53) | JAK1JAK2TYK2JAK3AURKA | |
| SCHEMBL2274413 | 0.83 | JAK2 (0.40) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL2274405 | 0.83 | HTT (0.35) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL2276802 | 0.82 | JAK1 (0.59) | JAK1JAK2TYK2JAK3AURKA | |
| SCHEMBL2224172 | 0.75 | JAK1 (0.52) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL2224772 | 0.73 | JAK1 (0.75) | JAK1JAK2TYK2JAK3AURKA | |
| SCHEMBL2278420 | 0.72 | JAK2 (0.41) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL2271654 | 0.72 | JAK1 (0.76) | JAK1JAK2TYK2JAK3AURKA | |
| SCHEMBL2278411 | 0.71 | CHRM4 (0.40) | JAK1JAK2 | |
| SCHEMBL2271626 | 0.69 | JAK2 (0.55) | JAK1JAK2TYK2JAK3AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2523957-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | F. Hoffmann-La Roche AG (CH) | 2012-11-21 | — | — | EP | disclosed |
| WO-2011086053-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2011-07-21 | — | — | WO | disclosed |