Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 16/20 | 0.58 |
| ▸ | WDR77 | Q9BQA1 | 7/20 | 0.54 |
| ▸ | METTL3 | Q86U44 | 7/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22716962 | 0.89 | PRMT5 (0.59) | PRMT5WDR77METTL3 | |
| SCHEMBL22716978 | 0.89 | PRMT5 (0.53) | PRMT5WDR77METTL3 | |
| SCHEMBL22717187 | 0.87 | PRMT5 (0.53) | PRMT5WDR77METTL3 | |
| SCHEMBL22717207 | 0.86 | PRMT5 (0.79) | PRMT5WDR77METTL3 | |
| SCHEMBL29485599 | 0.86 | PRMT5 (0.79) | PRMT5WDR77METTL3 | |
| SCHEMBL18572235 | 0.84 | PRMT5 (0.69) | PRMT5WDR77METTL3 | |
| SCHEMBL18572948 | 0.84 | PRMT5 (0.75) | PRMT5WDR77METTL3 | |
| SCHEMBL22716979 | 0.84 | PRMT5 (0.51) | PRMT5WDR77METTL3 | |
| SCHEMBL29485589 | 0.84 | PRMT5 (0.51) | PRMT5WDR77METTL3 | |
| SCHEMBL18571667 | 0.83 | PRMT5 (0.68) | PRMT5WDR77METTL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3976038-A1 | HETEROCYCLIC COMPOUNDS AS PRMT5 INHIBITORS | Angex Pharmaceutical, Inc. (US) | 2022-04-06 | — | — | EP | claimed |
| CN-114126614-A | Heterocyclic compounds as PRMT5 inhibitors | 安杰斯制药公司 | 2022-03-01 | — | — | CN | claimed |
| WO-2020243178-A1 | HETEROCYCLIC COMPOUNDS AS PRMT5 INHIBITORS | ANGEX PHARMACEUTICAL, INC. (US) | 2020-12-03 | — | — | WO | claimed |
| EP-3976038-A1 | HETEROCYCLIC COMPOUNDS AS PRMT5 INHIBITORS | Angex Pharmaceutical, Inc. (US) | 2022-04-06 | — | — | EP | disclosed |
| CN-114126614-A | Heterocyclic compounds as PRMT5 inhibitors | 安杰斯制药公司 | 2022-03-01 | — | — | CN | disclosed |
| WO-2020243178-A1 | HETEROCYCLIC COMPOUNDS AS PRMT5 INHIBITORS | ANGEX PHARMACEUTICAL, INC. (US) | 2020-12-03 | — | — | WO | disclosed |
| WO-2020243178-A1 | HETEROCYCLIC COMPOUNDS AS PRMT5 INHIBITORS | ANGEX PHARMACEUTICAL, INC. (US) | 2020-12-03 | — | — | WO | disclosed |