SCHEMBL22720583

SCHEMBL22720583

O=C(O)c1ncc2c(n1)CN(C(=O)O)CC2

nearest known ligand 0.41

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 18/20 0.41
CYP4F2 P78329 1/20 0.35
CYP4A11 Q02928 1/20 0.35
CDK2 P24941 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22440316 0.82 MAPK1 (0.42) MAPK1CDK2
SCHEMBL12497599 0.82 HSP90AB1 (0.47) MAPK1
SCHEMBL22981142 0.79 MAPK1 (0.42) MAPK1CDK2
SCHEMBL30793292 0.78 HSP90AA1 (0.48) MAPK1CDK2
SCHEMBL3134418 0.78 MAPK1 (0.48) MAPK1CDK2
SCHEMBL22980413 0.78 MAPK1 (0.41) MAPK1CDK2
SCHEMBL30675356 0.78 MAPK1 (0.41) MAPK1CDK2
SCHEMBL30613785 0.78 HTR2C (0.51) MAPK1
SCHEMBL12497152 0.75 MAPK1 (0.68) MAPK1
SCHEMBL3719148 0.75 HDAC1 (0.39) MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020239077-A1 NITROGEN-CONTAINING HETEROCYCLIC DERIVATIVE REGULATOR, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF 上海翰森生物医药科技有限公司 2020-12-03 WO disclosed