SCHEMBL22720674 — predicted protein targets

Predicted protein targets (top 17)

	gene	UniProt	supporting neighbours	confidence
▸	MAPK14	Q16539	3/20	0.38

▸	LCK	P06239	2/20	0.38

▸	SRC	P12931	2/20	0.38

▸	TEK	Q02763	1/20	0.38

▸	SCN4A	P35499	2/20	0.37

▸	BTK	Q06187	4/20	0.35

▸	TNK2	Q07912	1/20	0.35

▸	PLAUR	Q03405	1/20	0.35

▸	LTA4H	P09960	1/20	0.34

▸	ALK	Q9UM73	1/20	0.34

▸	GABRA1	P14867	1/20	0.33

▸	GABRG2	P18507	1/20	0.33

▸	GABRB3	P28472	1/20	0.33

▸	BRD4	O60885	1/20	0.33

▸	CA1	P00915	1/20	0.33

▸	CA2	P00918	1/20	0.33

▸	HRH3	Q9Y5N1	2/20	0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL22720850	0.91	SCN4A (0.38)	LCKSRCSCN4ABTKTNK2
SCHEMBL29439299	0.91	SCN4A (0.38)	LCKSRCSCN4ABTKTNK2
SCHEMBL22721166	0.91	SCN4A (0.38)	LCKSRCSCN4ABTKTNK2
SCHEMBL22721049	0.91	SCN4A (0.38)	LCKSRCSCN4ABTKTNK2
SCHEMBL5805292	0.84	PLAUR (0.42)	MAPK14LCKSRCTEKSCN4A
SCHEMBL28734234	0.83	SCN4A (0.32)	SCN4ABTK
SCHEMBL22721138	0.83	PLAUR (0.40)	MAPK14LCKSRCTEKSCN4A
SCHEMBL7047879	0.82	SCN4A (0.47)	MAPK14LCKSRCTEKSCN4A
SCHEMBL22720732	0.81	SCN4A (0.38)	MAPK14LCKSRCTEKSCN4A
SCHEMBL5804770	0.78	LCK (0.47)	MAPK14LCKSRCTEKSCN4A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2020239103-A1	BTK INHIBITOR RING DERIVATIVE, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL APPLICATION THEREOF	四川海思科制药有限公司	2020-12-03	—	—	WO	disclosed