SCHEMBL22720796

SCHEMBL22720796

Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)nn2C1CCN(C2CN(C3CNC3)C2)CC1

nearest known ligand 0.71

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BTK Q06187 20/20 0.71
NUDT14 O95848 2/20 0.71
NUDT5 Q9UKK9 2/20 0.71
LCK P06239 3/20 0.70
LYN P07948 2/20 0.70
SRC P12931 2/20 0.69
KDR P35968 2/20 0.69
TEK Q02763 1/20 0.69
EGFR P00533 3/20 0.63
TEC P42680 2/20 0.57
TXK P42681 2/20 0.57
BMX P51813 2/20 0.57
RIPK2 O43353 1/20 0.57
NR1I2 O75469 1/20 0.57
SLC22A3 O75751 1/20 0.57
LATS1 O95835 1/20 0.57
ABL1 P00519 1/20 0.57
ERBB2 P04626 1/20 0.57
FYN P06241 1/20 0.57
PGR P06401 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29439192 1.00 BTK (0.71) BTKNUDT14NUDT5LCKLYN
SCHEMBL22721008 1.00 BTK (0.71) BTKNUDT14NUDT5LCKLYN
SCHEMBL29439093 1.00 BTK (0.71) BTKNUDT14NUDT5LCKLYN
SCHEMBL22720894 0.99 BTK (0.71) BTKNUDT14NUDT5LCKLYN
SCHEMBL29439197 0.99 BTK (0.71) BTKNUDT14NUDT5LCKLYN
SCHEMBL22737304 0.96 BTK (0.68) BTKNUDT14NUDT5LCKLYN
SCHEMBL29439211 0.96 BTK (0.71) BTKNUDT14NUDT5LCKLYN
SCHEMBL22720917 0.96 BTK (0.71) BTKNUDT14NUDT5LCKLYN
SCHEMBL22720683 0.96 BTK (0.76) BTKNUDT14NUDT5LCKLYN
SCHEMBL29439227 0.96 BTK (0.76) BTKNUDT14NUDT5LCKLYN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118027041-A BTK inhibitor ring derivative and preparation method and pharmaceutical application thereof 西藏海思科制药有限公司 2024-05-14 CN disclosed
US-20240018147-A1 SALT OF COMPOUND FOR DEGRADING BTK, CRYSTAL FORM THEREOF, AND USE THEREOF IN MEDICINE HAISCO PHARMACEUTICALS PTE. LTD. (CN) 2024-01-18 US disclosed
US-20240018147-A1 SALT OF COMPOUND FOR DEGRADING BTK, CRYSTAL FORM THEREOF, AND USE THEREOF IN MEDICINE HAISCO PHARMACEUTICALS PTE. LTD. (CN) 2024-01-18 US disclosed
US-20240018147-A1 SALT OF COMPOUND FOR DEGRADING BTK, CRYSTAL FORM THEREOF, AND USE THEREOF IN MEDICINE HAISCO PHARMACEUTICALS PTE. LTD. (CN) 2024-01-18 US disclosed
CN-113544130-B BTK inhibitor ring derivative and preparation method and pharmaceutical application thereof 西藏海思科制药有限公司 2024-01-09 CN disclosed
US-20240002387-A1 METHOD FOR PREPARING BTK DEGRADING AGENT HAISCO PHARMACEUTICALS PTE. LTD. (SG) 2024-01-04 US disclosed
EP-4253384-A1 METHOD FOR PREPARING BTK DEGRADING AGENT Haisco Pharmaceuticals Pte. Ltd. (SG) 2023-10-04 EP disclosed
US-20230248833-A1 COMPOUND HAVING BTK KINASE DEGRADING ACTIVITY, AND PREPARATION METHOD AND PHARMACEUTICAL USE THEREFOR XIZANG HAISCO PHARMACEUTICAL CO., LTD. (CN) 2023-08-10 US disclosed
US-20230248833-A1 COMPOUND HAVING BTK KINASE DEGRADING ACTIVITY, AND PREPARATION METHOD AND PHARMACEUTICAL USE THEREFOR XIZANG HAISCO PHARMACEUTICAL CO., LTD. (CN) 2023-08-10 US disclosed
US-20230248833-A1 COMPOUND HAVING BTK KINASE DEGRADING ACTIVITY, AND PREPARATION METHOD AND PHARMACEUTICAL USE THEREFOR XIZANG HAISCO PHARMACEUTICAL CO., LTD. (CN) 2023-08-10 US disclosed
EP-4180432-A1 COMPOUND HAVING BTK KINASE DEGRADING ACTIVITY, AND PREPARATION METHOD AND PHARMACEUTICAL USE THEREFOR Sichuan Haisco Pharmaceutical Co., Ltd. (CN) 2023-05-17 EP disclosed
CN-116134028-A Compound capable of degrading BTK kinase, preparation method and pharmaceutical application thereof 四川海思科制药有限公司 2023-05-16 CN disclosed
US-11542266-B1 Substituted piperidines as BTK inhibitors HAISCO PHARMACEUTICALS PTE. LTD. (SG) 2023-01-03 US disclosed
US-11542266-B1 Substituted piperidines as BTK inhibitors HAISCO PHARMACEUTICALS PTE. LTD. (SG) 2023-01-03 US disclosed
CN-114539264-A Preparation method of BTK (benzene-toluene-xylene) degrading agent 海思科医药集团股份有限公司 2022-05-27 CN disclosed
EP-3978496-A1 BTK INHIBITOR RING DERIVATIVE, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL APPLICATION THEREOF Haisco Pharmaceuticals Pte. Ltd. (SG) 2022-04-06 EP disclosed
WO-2022052950-A1 SALT OF COMPOUND FOR DEGRADING BTK, CRYSTAL FORM THEREOF, AND USE THEREOF IN MEDICINE 海思科医药集团股份有限公司 2022-03-17 WO disclosed
WO-2022007824-A1 COMPOUND HAVING BTK KINASE DEGRADING ACTIVITY, AND PREPARATION METHOD AND PHARMACEUTICAL USE THEREFOR 四川海思科制药有限公司 2022-01-13 WO disclosed
WO-2020239103-A1 BTK INHIBITOR RING DERIVATIVE, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL APPLICATION THEREOF 四川海思科制药有限公司 2020-12-03 WO disclosed
WO-2020239103-A1 BTK INHIBITOR RING DERIVATIVE, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL APPLICATION THEREOF 四川海思科制药有限公司 2020-12-03 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240018147-A1 SALT OF COMPOUND FOR DEGRADING BTK, CRYSTAL FORM THEREOF, AND USE THEREOF IN MEDICINE BTK, SYK, LYN BTK 1/4885NUDT14 2377/4885NUDT5 2641/4885
US-11542266-B1 Substituted piperidines as BTK inhibitors BTK, BLK, SYK BTK 1/4885NUDT14 3824/4885NUDT5 2932/4885
US-20230248833-A1 COMPOUND HAVING BTK KINASE DEGRADING ACTIVITY, AND PREPARATION METHOD AND PHARMACEUTICAL USE THEREFOR BTK, WEE1, WEE2 BTK 1/4885NUDT14 3438/4885NUDT5 3516/4885
US-20240002387-A1 METHOD FOR PREPARING BTK DEGRADING AGENT BTK, SYK, LYN BTK 1/4885NUDT14 1825/4885NUDT5 935/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.