Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 2/20 | 0.37 |
| ▸ | MMP9 | P14780 | 2/20 | 0.37 |
| ▸ | SCN4A | P35499 | 1/20 | 0.36 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.35 |
| ▸ | BTK | Q06187 | 4/20 | 0.35 |
| ▸ | KDM2B | Q8NHM5 | 3/20 | 0.34 |
| ▸ | APP | P05067 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22720878 | 0.90 | SCN4A (0.42) | SCN4ATNK2BTK | |
| SCHEMBL22720927 | 0.87 | SCN4A (0.40) | SCN4ATNK2BTK | |
| SCHEMBL28643229 | 0.84 | PLAUR (0.37) | MMP2MMP9SCN4ATNK2BTK | |
| SCHEMBL5805292 | 0.81 | PLAUR (0.42) | SCN4ATNK2BTK | |
| SCHEMBL27577918 | 0.81 | SCN4A (0.49) | SCN4ATNK2BTK | |
| SCHEMBL5803668 | 0.78 | DRD4 (0.54) | SCN4A | |
| SCHEMBL6640044 | 0.78 | BTK (0.46) | SCN4ATNK2BTKKDM2B | |
| SCHEMBL22721138 | 0.78 | PLAUR (0.40) | SCN4ATNK2BTK | |
| SCHEMBL22720731 | 0.78 | SCN4A (0.40) | SCN4ATNK2BTK | |
| SCHEMBL5804770 | 0.77 | LCK (0.47) | SCN4ATNK2BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118027041-A | BTK inhibitor ring derivative and preparation method and pharmaceutical application thereof | 西藏海思科制药有限公司 | 2024-05-14 | — | — | CN | disclosed |
| CN-113544130-B | BTK inhibitor ring derivative and preparation method and pharmaceutical application thereof | 西藏海思科制药有限公司 | 2024-01-09 | — | — | CN | disclosed |
| CN-113544130-A | BTK inhibitor ring derivative, preparation method and pharmaceutical application thereof | 四川海思科制药有限公司 | 2021-10-22 | — | — | CN | disclosed |
| WO-2020239103-A1 | BTK INHIBITOR RING DERIVATIVE, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL APPLICATION THEREOF | 四川海思科制药有限公司 | 2020-12-03 | — | — | WO | disclosed |