Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP46A1 | Q9Y6A2 | 9/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22728286 | 0.87 | CYP46A1 (0.62) | CYP46A1CYP2C19CYP3A4CYP2C8CYP2C9 | |
| SCHEMBL22719467 | 0.83 | CYP46A1 (0.59) | CYP46A1CYP2C19CYP3A4CYP2C8CYP2C9 | |
| SCHEMBL29453740 | 0.83 | CYP46A1 (0.59) | CYP46A1CYP2C19CYP3A4CYP2C8CYP2C9 | |
| SCHEMBL22728279 | 0.78 | CYP46A1 (0.56) | CYP46A1CYP2C19CYP3A4CYP2C8CYP2C9 | |
| SCHEMBL22728305 | 0.76 | CYP46A1 (0.62) | CYP46A1CYP2C19CYP3A4CYP2C8CYP2C9 | |
| SCHEMBL21215249 | 0.75 | CYP46A1 (0.76) | CYP46A1CYP2C19CYP3A4CYP2C8CYP2C9 | |
| SCHEMBL22728300 | 0.75 | CYP46A1 (0.79) | CYP46A1CYP2C19CYP3A4CYP2C8CYP2C9 | |
| SCHEMBL14848975 | 0.74 | CYP46A1 (0.74) | CYP46A1CYP2C19CYP3A4CYP2C8CYP2C9 | |
| Soticlestat SCHEMBL14841089 | 0.74 | CYP46A1 (1.00) | CYP46A1CYP2C19CYP3A4CYP2C8CYP2C9 | |
| Soticlestat SCHEMBL29469585 | 0.74 | CYP46A1 (1.00) | CYP46A1CYP2C19CYP3A4CYP2C8CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020243027-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS OF USE | SAGE THERAPEUTICS, INC. (US) | 2020-12-03 | — | — | WO | disclosed |