Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHA2 | P29317 | 2/20 | 0.65 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.64 |
| ▸ | EGFR | P00533 | 2/20 | 0.63 |
| ▸ | NFKBIA | P25963 | 1/20 | 0.45 |
| ▸ | AKT1 | P31749 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19003330 | 0.88 | PTGER2 (0.69) | EPHA2PTGER2EGFRNFKBIAAKT1 | |
| SCHEMBL23598422 | 0.88 | PTGER2 (0.66) | EPHA2PTGER2EGFRNFKBIAAKT1 | |
| SCHEMBL23598456 | 0.88 | PTGER2 (0.69) | EPHA2PTGER2EGFRNFKBIAAKT1 | |
| SCHEMBL19003397 | 0.88 | PTGER2 (0.66) | EPHA2PTGER2EGFRNFKBIAAKT1 | |
| SCHEMBL19003414 | 0.86 | PTGER2 (0.71) | EPHA2PTGER2EGFRNFKBIAAKT1 | |
| SCHEMBL24157885 | 0.86 | PTGER2 (0.71) | EPHA2PTGER2EGFRNFKBIAAKT1 | |
| SCHEMBL19003325 | 0.86 | PTGER2 (0.71) | EPHA2PTGER2EGFRNFKBIAAKT1 | |
| SCHEMBL19003327 | 0.86 | PTGER2 (0.71) | EPHA2PTGER2EGFRNFKBIAAKT1 | |
| SCHEMBL19003323 | 0.86 | PTGER2 (0.71) | EPHA2PTGER2EGFRNFKBIAAKT1 | |
| SCHEMBL19003321 | 0.86 | EPHA2 (0.75) | EPHA2PTGER2EGFRNFKBIAAKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11149065-B2 | One-bead-two-compound macrocyclic library and methods of preparation and use | UNIVERSITY OF SOUTH FLORIDA (US) | 2021-10-19 | — | — | US | disclosed |
| US-20200377552-A1 | ONE-BEAD-TWO-COMPOUND MACROCYCLIC LIBRARY AND METHODS OF PREPARATION AND USE | UNIVERSITY OF SOUTH FLORIDA | 2020-12-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11149065-B2 | One-bead-two-compound macrocyclic library and methods of preparation and use | EPHA2, EPHA1, EPHB2 | EPHA2 1/4885PTGER2 187/4885EGFR 26/4885 |
| US-20200377552-A1 | ONE-BEAD-TWO-COMPOUND MACROCYCLIC LIBRARY AND METHODS OF PREPARATION AND USE | EPHA2, EPHA1, EPHB2 | EPHA2 1/4885PTGER2 187/4885EGFR 26/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.