Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLQ | O75417 | 8/20 | 0.58 |
| ▸ | JAK2 | O60674 | 2/20 | 0.47 |
| ▸ | JAK1 | P23458 | 2/20 | 0.47 |
| ▸ | TYK2 | P29597 | 2/20 | 0.47 |
| ▸ | JAK3 | P52333 | 2/20 | 0.47 |
| ▸ | CDC7 | O00311 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | NNMT | P40261 | 1/20 | 0.46 |
| ▸ | CSF1R | P07333 | 1/20 | 0.45 |
| ▸ | IKBKB | O14920 | 1/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.44 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.43 |
| ▸ | CDK9 | P50750 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29694876 | 1.00 | POLQ (0.58) | POLQJAK2JAK1TYK2JAK3 | |
| SCHEMBL29574862 | 1.00 | POLQ (0.58) | POLQJAK2JAK1TYK2JAK3 | |
| SCHEMBL22732085 | 0.90 | POLQ (0.51) | POLQJAK2JAK1TYK2JAK3 | |
| SCHEMBL29575107 | 0.87 | POLQ (0.60) | POLQAKR1C3AKR1C2 | |
| SCHEMBL22717424 | 0.87 | POLQ (0.60) | POLQAKR1C3AKR1C2 | |
| SCHEMBL29574532 | 0.87 | POLQ (0.60) | POLQAKR1C3AKR1C2 | |
| SCHEMBL22717466 | 0.86 | POLQ (0.61) | POLQAKR1C3AKR1C2 | |
| SCHEMBL31019111 | 0.86 | POLQ (0.61) | POLQAKR1C3AKR1C2 | |
| SCHEMBL30017905 | 0.86 | POLQ (0.61) | POLQAKR1C3AKR1C2 | |
| SCHEMBL22732080 | 0.84 | POLQ (0.60) | POLQCDC7NNMTIKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114127062-A | Thiadiazolyl derivatives as inhibitors of DNA polymerase Theta | 伊迪亚生物科学有限公司 | 2022-03-01 | — | — | CN | disclosed |
| WO-2020243459-A1 | THIADIAZOLYL DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | IDEAYA BIOSCIENCES, INC. (US) | 2020-12-03 | — | — | WO | disclosed |