Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 9/20 | 0.47 |
| ▸ | JAK1 | P23458 | 8/20 | 0.47 |
| ▸ | TYK2 | P29597 | 6/20 | 0.47 |
| ▸ | JAK3 | P52333 | 5/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CCR8 | P51685 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2274090 | 0.89 | JAK1 (0.47) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL2277331 | 0.87 | JAK2 (0.47) | JAK2JAK1TYK2JAK3HTT | |
| SCHEMBL2279700 | 0.84 | JAK2 (0.48) | JAK2JAK1TYK2JAK3HTT | |
| SCHEMBL2271023 | 0.84 | JAK2 (0.43) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL2276088 | 0.82 | JAK2 (0.46) | JAK2JAK1TYK2JAK3HTT | |
| SCHEMBL2272535 | 0.80 | JAK1 (0.45) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL2277601 | 0.80 | JAK1 (0.45) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL2278052 | 0.79 | JAK2 (0.48) | JAK2JAK1TYK2JAK3KMT2A | |
| SCHEMBL2277282 | 0.79 | JAK1 (0.44) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL2278010 | 0.78 | JAK1 (0.44) | JAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2523957-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | F. Hoffmann-La Roche AG (CH) | 2012-11-21 | — | — | EP | disclosed |
| WO-2011086053-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2011-07-21 | — | — | WO | disclosed |