⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15976749 | 0.87 | KMT2A (0.33) | — | |
| SCHEMBL20851935 | 0.86 | MAPK1 (0.35) | — | |
| SCHEMBL516176 | 0.86 | MAPK1 (0.35) | — | |
| SCHEMBL20840622 | 0.86 | MAPK1 (0.35) | — | |
| SCHEMBL22734115 | 0.84 | KMT2A (0.38) | — | |
| SCHEMBL22734104 | 0.84 | KMT2A (0.40) | — | |
| SCHEMBL22734105 | 0.83 | KMT2A (0.43) | — | |
| SCHEMBL22264651 | 0.83 | PDE4D (0.33) | — | |
| SCHEMBL31491275 | 0.83 | TYRO3 (0.36) | — | |
| SCHEMBL31491308 | 0.82 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3724195-B1 | SUBSTITUTED TETRAHYDROPYRAN DIHYDROTHIENOPYRIMIDINES AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | UNION THERAPEUTICS AS (DK) | 2023-12-27 | — | — | EP | disclosed |
| US-11299497-B2 | Substituted tetrahydropyran dihydrothienopyrimidines and their use as phosphodiesterase inhibitors | UNION therapeutics A/S (DK) | 2022-04-12 | — | — | US | disclosed |
| US-20200385400-A1 | SUBSTITUTED TETRAHYDROPYRAN DIHYDROTHIENOPYRIMIDINES AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | UNION therapeutics A/S (DK) | 2020-12-10 | — | — | US | disclosed |