Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 15/20 | 0.43 |
| ▸ | JAK2 | O60674 | 5/20 | 0.43 |
| ▸ | HTR6 | P50406 | 5/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 2/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 3/20 | 0.34 |
| ▸ | JAK3 | P52333 | 3/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2273561 | 1.00 | JAK1 (0.43) | JAK1JAK2HTR6MAOBDRD3 | |
| SCHEMBL30480399 | 0.93 | JAK1 (0.36) | JAK1JAK2HTR6TYK2JAK3 | |
| SCHEMBL25699287 | 0.89 | JAK1 (0.42) | JAK1JAK2HTR6MAOBTYK2 | |
| SCHEMBL29460490 | 0.89 | JAK1 (0.42) | JAK1JAK2HTR6MAOBTYK2 | |
| SCHEMBL2223896 | 0.89 | JAK1 (0.42) | JAK1JAK2HTR6MAOBTYK2 | |
| SCHEMBL25283735 | 0.89 | JAK1 (0.42) | JAK1JAK2HTR6MAOBTYK2 | |
| SCHEMBL25241529 | 0.89 | JAK1 (0.42) | JAK1JAK2HTR6MAOBTYK2 | |
| SCHEMBL30995752 | 0.89 | JAK1 (0.42) | JAK1JAK2HTR6MAOBTYK2 | |
| SCHEMBL2224738 | 0.87 | JAK1 (0.46) | JAK1JAK2HTR6DRD3DRD2 | |
| SCHEMBL2280654 | 0.85 | JAK1 (0.45) | JAK1JAK2HTR6MAOBTYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2523957-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | F. Hoffmann-La Roche AG (CH) | 2012-11-21 | — | — | EP | disclosed |
| WO-2011086053-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2011-07-21 | — | — | WO | disclosed |