Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 5/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.34 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.34 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29480712 | 1.00 | GRM4 (0.36) | GRM4AURKAAURKBINCENPTPX2 | |
| SCHEMBL29480474 | 0.90 | GRM4 (0.35) | GRM4AURKAAURKBINCENPTPX2 | |
| SCHEMBL22736183 | 0.90 | GRM4 (0.35) | GRM4AURKAAURKBINCENPTPX2 | |
| SCHEMBL22735729 | 0.85 | GRM4 (0.33) | GRM4AURKAAURKBINCENPTPX2 | |
| SCHEMBL29480488 | 0.85 | GRM4 (0.33) | GRM4AURKAAURKBINCENPTPX2 | |
| SCHEMBL22736027 | 0.83 | HDAC4 (0.34) | GRM4AURKAAURKBINCENPTPX2 | |
| SCHEMBL29480597 | 0.83 | HDAC4 (0.34) | GRM4AURKAAURKBINCENPTPX2 | |
| SCHEMBL22736185 | 0.82 | GRM4 (0.32) | GRM4AURKAAURKBINCENPTPX2 | |
| SCHEMBL29567439 | 0.82 | GRM4 (0.32) | GRM4AURKAAURKBINCENPTPX2 | |
| SCHEMBL22736499 | 0.82 | JAK2 (0.34) | GRM4HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020240586-A1 | NOVEL COMPOUNDS FOR INHIBITION OF JANUS KINASE 1 | MANKIND PHARMA LTD. (IN) | 2020-12-03 | — | — | WO | disclosed |