Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4A | O75164 | 9/20 | 0.39 |
| ▸ | KDM4B | O94953 | 9/20 | 0.39 |
| ▸ | KDM5C | P41229 | 9/20 | 0.39 |
| ▸ | KDM5B | Q9UGL1 | 9/20 | 0.39 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.33 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.32 |
| ▸ | CDK9 | P50750 | 1/20 | 0.32 |
| ▸ | CASP7 | P55210 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.31 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.31 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29480482 | 1.00 | KDM4A (0.39) | KDM4AKDM4BKDM5CKDM5BKDM2A | |
| SCHEMBL22736498 | 0.95 | KDM4A (0.36) | KDM4AKDM4BKDM5CKDM5BKDM2A | |
| SCHEMBL29480599 | 0.95 | KDM4A (0.36) | KDM4AKDM4BKDM5CKDM5BKDM2A | |
| SCHEMBL29480602 | 0.95 | KDM4A (0.36) | KDM4AKDM4BKDM5CKDM5BKDM2A | |
| SCHEMBL22736501 | 0.95 | KDM4A (0.36) | KDM4AKDM4BKDM5CKDM5BKDM2A | |
| SCHEMBL22735866 | 0.92 | KDM4A (0.33) | KDM4AKDM4BKDM5CKDM5BCASP3 | |
| SCHEMBL29480521 | 0.92 | KDM4A (0.33) | KDM4AKDM4BKDM5CKDM5BCASP3 | |
| SCHEMBL22735904 | 0.91 | KDM4A (0.36) | KDM4AKDM4BKDM5CKDM5BHDAC4 | |
| SCHEMBL29480485 | 0.91 | KDM4A (0.36) | KDM4AKDM4BKDM5CKDM5BHDAC4 | |
| SCHEMBL22736027 | 0.91 | HDAC4 (0.34) | HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020240586-A1 | NOVEL COMPOUNDS FOR INHIBITION OF JANUS KINASE 1 | MANKIND PHARMA LTD. (IN) | 2020-12-03 | — | — | WO | disclosed |