Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MELK | Q14680 | 6/20 | 0.34 |
| ▸ | KDM4A | O75164 | 2/20 | 0.33 |
| ▸ | KDM4B | O94953 | 2/20 | 0.33 |
| ▸ | KDM5C | P41229 | 2/20 | 0.33 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.32 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.32 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.32 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.30 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.30 |
| ▸ | CDC42BPB | Q9Y5S2 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29567596 | 1.00 | MELK (0.34) | MELKKDM4AKDM4BKDM5CKDM5B | |
| SCHEMBL22736503 | 0.93 | MELK (0.34) | MELKKDM4AKDM4BKDM5CKDM5B | |
| SCHEMBL29567670 | 0.93 | MELK (0.34) | MELKKDM4AKDM4BKDM5CKDM5B | |
| SCHEMBL22736186 | 0.91 | MAPK1 (0.42) | MELKKDM4AKDM4BKDM5CKDM5B | |
| SCHEMBL29567713 | 0.91 | MAPK1 (0.42) | MELKKDM4AKDM4BKDM5CKDM5B | |
| SCHEMBL22736182 | 0.87 | JAK2 (0.32) | JAK2 | |
| SCHEMBL22735800 | 0.86 | GRM4 (0.32) | MAPK1AURKAAURKBINCENPTPX2 | |
| SCHEMBL29480663 | 0.86 | GRM4 (0.32) | MAPK1AURKAAURKBINCENPTPX2 | |
| SCHEMBL22716928 | 0.86 | GRM4 (0.33) | KDM4AKDM4BKDM5CKDM5BMAPK1 | |
| SCHEMBL29567676 | 0.86 | GRM4 (0.33) | KDM4AKDM4BKDM5CKDM5BMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020240586-A1 | NOVEL COMPOUNDS FOR INHIBITION OF JANUS KINASE 1 | MANKIND PHARMA LTD. (IN) | 2020-12-03 | — | — | WO | disclosed |