Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK2 | O43353 | 9/20 | 0.34 |
| ▸ | GCG | P01275 | 7/20 | 0.33 |
| ▸ | JAK2 | O60674 | 2/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | TDO2 | P48775 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29480767 | 1.00 | RIPK2 (0.34) | RIPK2GCGJAK2JAK1TDO2 | |
| SCHEMBL29480497 | 0.90 | RIPK2 (0.34) | RIPK2GCGJAK2 | |
| SCHEMBL22736254 | 0.90 | RIPK2 (0.34) | RIPK2GCGJAK2 | |
| SCHEMBL22736259 | 0.89 | PDK2 (0.35) | GCGJAK2JAK1 | |
| SCHEMBL29567075 | 0.89 | PDK2 (0.35) | GCGJAK2JAK1 | |
| SCHEMBL22736177 | 0.88 | PDK2 (0.36) | GCGJAK2JAK1 | |
| SCHEMBL22736028 | 0.88 | PDK2 (0.36) | GCGJAK2JAK1 | |
| SCHEMBL29480640 | 0.87 | JAK2 (0.31) | GCGJAK2 | |
| SCHEMBL22716870 | 0.87 | JAK2 (0.31) | GCGJAK2 | |
| SCHEMBL29480711 | 0.85 | RIPK2 (0.35) | RIPK2GCG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020240586-A1 | NOVEL COMPOUNDS FOR INHIBITION OF JANUS KINASE 1 | MANKIND PHARMA LTD. (IN) | 2020-12-03 | — | — | WO | disclosed |