Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.31 |
| ▸ | MTOR | P42345 | 1/20 | 0.31 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 2/20 | 0.31 |
| ▸ | JAK1 | P23458 | 1/20 | 0.31 |
| ▸ | TYK2 | P29597 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.31 |
| ▸ | GCG | P01275 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22716739 | 0.89 | JAK2 (0.33) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL29567685 | 0.89 | JAK2 (0.33) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL22716737 | 0.89 | JAK2 (0.33) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL29567322 | 0.89 | JAK2 (0.33) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL22736539 | 0.89 | JAK2 (0.31) | JAK2JAK1TYK2JAK3GCG | |
| SCHEMBL29480732 | 0.89 | JAK2 (0.31) | JAK2JAK1TYK2JAK3GCG | |
| SCHEMBL22736008 | 0.88 | KDM4A (0.33) | JAK2JAK1TYK2JAK3GCG | |
| SCHEMBL29567316 | 0.88 | KDM4A (0.33) | JAK2JAK1TYK2JAK3GCG | |
| SCHEMBL22735791 | 0.87 | JAK2 (0.33) | JAK2JAK1TYK2JAK3GCG | |
| SCHEMBL22736486 | 0.87 | JAK2 (0.33) | JAK2JAK1TYK2JAK3GCG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020240586-A1 | NOVEL COMPOUNDS FOR INHIBITION OF JANUS KINASE 1 | MANKIND PHARMA LTD. (IN) | 2020-12-03 | — | — | WO | disclosed |