Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | GRM4 | Q14833 | 3/20 | 0.33 |
| ▸ | MELK | Q14680 | 2/20 | 0.33 |
| ▸ | KDM4A | O75164 | 3/20 | 0.32 |
| ▸ | KDM4B | O94953 | 3/20 | 0.32 |
| ▸ | KDM5C | P41229 | 3/20 | 0.32 |
| ▸ | KDM5B | Q9UGL1 | 3/20 | 0.32 |
| ▸ | CCNC | P24863 | 1/20 | 0.32 |
| ▸ | CDK8 | P49336 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29567579 | 1.00 | MAPK1 (0.38) | MAPK1GRM4MELKKDM4AKDM4B | |
| SCHEMBL29567713 | 0.92 | MAPK1 (0.42) | MAPK1GRM4MELKKDM4AKDM4B | |
| SCHEMBL22736186 | 0.92 | MAPK1 (0.42) | MAPK1GRM4MELKKDM4AKDM4B | |
| SCHEMBL22736503 | 0.90 | MELK (0.34) | MAPK1GRM4MELKKDM4AKDM4B | |
| SCHEMBL29567670 | 0.90 | MELK (0.34) | MAPK1GRM4MELKKDM4AKDM4B | |
| SCHEMBL29567903 | 0.87 | MAPK1 (0.34) | MAPK1GRM4MELKKDM4AKDM4B | |
| SCHEMBL22736180 | 0.87 | MAPK1 (0.34) | MAPK1GRM4MELKKDM4AKDM4B | |
| SCHEMBL22736024 | 0.87 | GRM4 (0.36) | MAPK1GRM4CCNCCDK8 | |
| SCHEMBL22735745 | 0.84 | GRM4 (0.34) | MAPK1GRM4 | |
| SCHEMBL29567619 | 0.84 | GRM4 (0.34) | MAPK1GRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020240586-A1 | NOVEL COMPOUNDS FOR INHIBITION OF JANUS KINASE 1 | MANKIND PHARMA LTD. (IN) | 2020-12-03 | — | — | WO | disclosed |