Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 8/20 | 0.39 |
| ▸ | MELK | Q14680 | 2/20 | 0.37 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 4/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 3/20 | 0.33 |
| ▸ | JAK3 | P52333 | 2/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.32 |
| ▸ | CTSC | P53634 | 2/20 | 0.32 |
| ▸ | CTSK | P43235 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29480577 | 1.00 | GRM4 (0.39) | GRM4MELKFEN1JAK2BTK | |
| SCHEMBL29480589 | 0.86 | MELK (0.38) | GRM4MELKKCNH2 | |
| SCHEMBL22736085 | 0.86 | MELK (0.38) | GRM4MELKKCNH2 | |
| SCHEMBL22736159 | 0.84 | GRM4 (0.45) | GRM4MELKJAK2JAK1JAK3 | |
| SCHEMBL22716872 | 0.82 | GRM4 (0.44) | GRM4MELKHTR2BMTNR1AKCNH2 | |
| SCHEMBL29480526 | 0.82 | GRM4 (0.44) | GRM4MELKHTR2BMTNR1AKCNH2 | |
| SCHEMBL29480566 | 0.81 | GRM4 (0.39) | GRM4MELKFEN1JAK2JAK1 | |
| SCHEMBL22736084 | 0.81 | GRM4 (0.39) | GRM4MELKFEN1JAK2JAK1 | |
| SCHEMBL22736010 | 0.78 | KDM5A (0.38) | GRM4JAK2JAK1JAK3TYK2 | |
| SCHEMBL22735993 | 0.76 | EGLN1 (0.37) | GRM4JAK2JAK1JAK3TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020240586-A1 | NOVEL COMPOUNDS FOR INHIBITION OF JANUS KINASE 1 | MANKIND PHARMA LTD. (IN) | 2020-12-03 | — | — | WO | disclosed |