Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 3/20 | 0.41 |
| ▸ | GRM4 | Q14833 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.34 |
| ▸ | KDM4A | O75164 | 3/20 | 0.34 |
| ▸ | KDM4B | O94953 | 3/20 | 0.34 |
| ▸ | KDM5C | P41229 | 3/20 | 0.34 |
| ▸ | KDM5B | Q9UGL1 | 3/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.34 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.34 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 3/20 | 0.32 |
| ▸ | JAK1 | P23458 | 3/20 | 0.32 |
| ▸ | JAK3 | P52333 | 2/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29823952 | 1.00 | GRM5 (0.41) | GRM5GRM4KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL29480471 | 0.84 | EGLN1 (0.37) | GRM5GRM4EGLN1AURKAAURKB | |
| SCHEMBL22735993 | 0.84 | EGLN1 (0.37) | GRM5GRM4EGLN1AURKAAURKB | |
| Hydrochloric Acid SCHEMBL29480556 | 0.83 | EGLN1 (0.36) | GRM5GRM4EGLN1AURKAAURKB | |
| SCHEMBL22736083 | 0.82 | GRM4 (0.35) | GRM5GRM4EGLN1AURKAAURKB | |
| SCHEMBL29480594 | 0.82 | GRM4 (0.35) | GRM5GRM4EGLN1AURKAAURKB | |
| SCHEMBL22735731 | 0.81 | GRM4 (0.35) | GRM5GRM4AURKAAURKBINCENP | |
| SCHEMBL29480465 | 0.81 | GRM4 (0.35) | GRM5GRM4AURKAAURKBINCENP | |
| SCHEMBL31158292 | 0.80 | GRM4 (0.58) | GRM5GRM4EGLN1KDM4AKDM4B | |
| SCHEMBL22736505 | 0.80 | GRM4 (0.58) | GRM5GRM4EGLN1KDM4AKDM4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020240586-A1 | NOVEL COMPOUNDS FOR INHIBITION OF JANUS KINASE 1 | MANKIND PHARMA LTD. (IN) | 2020-12-03 | — | — | WO | disclosed |