Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 4/20 | 0.38 |
| ▸ | VHL | P40337 | 1/20 | 0.38 |
| ▸ | KDM5A | P29375 | 1/20 | 0.36 |
| ▸ | KDM4A | O75164 | 1/20 | 0.35 |
| ▸ | KDM4B | O94953 | 1/20 | 0.35 |
| ▸ | KDM5C | P41229 | 1/20 | 0.35 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 2/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.34 |
| ▸ | INCENP | Q9NQS7 | 2/20 | 0.34 |
| ▸ | TPX2 | Q9ULW0 | 2/20 | 0.34 |
| ▸ | EGLN1 | Q9GZT9 | 5/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29480555 | 1.00 | GRM4 (0.38) | GRM4VHLKDM5AKDM4AKDM4B | |
| SCHEMBL22736006 | 0.86 | GRM4 (0.36) | GRM4KDM4AKDM4BKDM5CKDM5B | |
| SCHEMBL29480471 | 0.86 | EGLN1 (0.37) | GRM4AURKAAURKBINCENPTPX2 | |
| SCHEMBL29567447 | 0.86 | GRM4 (0.36) | GRM4KDM4AKDM4BKDM5CKDM5B | |
| SCHEMBL22735993 | 0.86 | EGLN1 (0.37) | GRM4AURKAAURKBINCENPTPX2 | |
| Hydrochloric Acid SCHEMBL29480556 | 0.85 | EGLN1 (0.36) | GRM4AURKAAURKBINCENPTPX2 | |
| SCHEMBL22736489 | 0.84 | GRM4 (0.33) | GRM4KDM4AKDM4BKDM5CKDM5B | |
| SCHEMBL29567716 | 0.84 | GRM4 (0.33) | GRM4KDM4AKDM4BKDM5CKDM5B | |
| SCHEMBL22736278 | 0.84 | GRM4 (0.35) | GRM4KDM4AKDM4BKDM5CKDM5B | |
| SCHEMBL29567624 | 0.84 | GRM4 (0.35) | GRM4KDM4AKDM4BKDM5CKDM5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020240586-A1 | NOVEL COMPOUNDS FOR INHIBITION OF JANUS KINASE 1 | MANKIND PHARMA LTD. (IN) | 2020-12-03 | — | — | WO | disclosed |