Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.36 |
| ▸ | GRM4 | Q14833 | 8/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.30 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.30 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.30 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.30 |
| ▸ | HTR2B | P41595 | 1/20 | 0.30 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | JAK1 | P23458 | 1/20 | 0.30 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29480500 | 1.00 | IRAK4 (0.36) | IRAK4GRM4AURKAAURKBINCENP | |
| SCHEMBL22736490 | 0.86 | GRM4 (0.36) | GRM4AURKAAURKBINCENPTPX2 | |
| SCHEMBL22735881 | 0.82 | GRM4 (0.40) | GRM4AURKAAURKBINCENPTPX2 | |
| SCHEMBL29480552 | 0.82 | GRM4 (0.35) | GRM4AURKAAURKBINCENPTPX2 | |
| SCHEMBL22736488 | 0.82 | GRM4 (0.35) | GRM4AURKAAURKBINCENPTPX2 | |
| SCHEMBL22736484 | 0.82 | GRM4 (0.35) | GRM4AURKAAURKBINCENPTPX2 | |
| SCHEMBL22735882 | 0.81 | JAK2 (0.32) | GRM4JAK1 | |
| SCHEMBL31158292 | 0.77 | GRM4 (0.58) | GRM4AURKAAURKBINCENPTPX2 | |
| SCHEMBL22736505 | 0.77 | GRM4 (0.58) | GRM4AURKAAURKBINCENPTPX2 | |
| SCHEMBL22736286 | 0.76 | GRM4 (0.34) | GRM4JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020240586-A1 | NOVEL COMPOUNDS FOR INHIBITION OF JANUS KINASE 1 | MANKIND PHARMA LTD. (IN) | 2020-12-03 | — | — | WO | disclosed |