Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K5 | Q99683 | 20/20 | 0.43 |
| ▸ | AKT1 | P31749 | 9/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL943740 | 0.80 | MAP3K5 (0.67) | MAP3K5 | |
| SCHEMBL944011 | 0.78 | MAP3K5 (0.55) | MAP3K5AKT1 | |
| SCHEMBL945361 | 0.78 | MAP3K5 (0.67) | MAP3K5 | |
| SCHEMBL945438 | 0.77 | MAP3K5 (0.57) | MAP3K5AKT1 | |
| SCHEMBL944497 | 0.76 | MAP3K5 (0.67) | MAP3K5 | |
| SCHEMBL947785 | 0.76 | MAP3K5 (0.56) | MAP3K5AKT1 | |
| SCHEMBL945209 | 0.76 | MAP3K5 (0.71) | MAP3K5AKT1 | |
| SCHEMBL22738980 | 0.76 | MAP3K5 (0.41) | MAP3K5AKT1 | |
| SCHEMBL945769 | 0.75 | MAP3K5 (0.53) | MAP3K5AKT1 | |
| SCHEMBL232728 | 0.75 | MAP3K5 (0.53) | MAP3K5AKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3363797-B1 | ORAL DOSAGE FORM OF APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS | GILEAD SCIENCES INC (US) | 2020-12-02 | — | — | EP | disclosed |