Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.43 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | MEF2D | Q14814 | 1/20 | 0.43 |
| ▸ | PTPRC | P08575 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21684122 | 0.83 | GAA (0.54) | GAASMN1; SMN2ALDH1A1HPGDMAPT | |
| SCHEMBL22743025 | 0.79 | GAA (0.49) | GAASMN1; SMN2ALDH1A1HPGDMAPT | |
| SCHEMBL22743033 | 0.79 | SMN1; SMN2 (0.52) | GAASMN1; SMN2ALDH1A1HPGDMAPT | |
| SCHEMBL22742984 | 0.76 | GAA (0.63) | GAASMN1; SMN2ALDH1A1HPGDMAPT | |
| SCHEMBL22743379 | 0.75 | SMN1; SMN2 (0.51) | GAASMN1; SMN2ALDH1A1MAPTL3MBTL1 | |
| SCHEMBL22743591 | 0.75 | SMN1; SMN2 (0.51) | GAASMN1; SMN2ALDH1A1MAPTL3MBTL1 | |
| SCHEMBL21682036 | 0.75 | POLB (0.69) | SMN1; SMN2ALDH1A1HPGDMAPTKDM4E | |
| SCHEMBL24137556 | 0.74 | KMT2A (0.71) | GAASMN1; SMN2ALDH1A1MAPTKDM4E | |
| SCHEMBL22743019 | 0.74 | POLB (0.74) | GAASMN1; SMN2ALDH1A1HPGDMAPT | |
| SCHEMBL22743592 | 0.72 | SMN1; SMN2 (0.52) | GAASMN1; SMN2ALDH1A1HPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020243178-A1 | HETEROCYCLIC COMPOUNDS AS PRMT5 INHIBITORS | ANGEX PHARMACEUTICAL, INC. (US) | 2020-12-03 | — | — | WO | disclosed |