Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | JAK1 | P23458 | 4/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.39 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2276041 | 0.86 | JAK1 (0.48) | JAK1CYP2C19LMNAJAK2TYK2 | |
| SCHEMBL2223730 | 0.84 | JAK1 (0.53) | JAK1CYP2C19JAK2TYK2JAK3 | |
| SCHEMBL2273826 | 0.83 | JAK1 (0.48) | JAK1CYP2C19JAK2TYK2JAK3 | |
| SCHEMBL2273246 | 0.82 | JAK1 (0.52) | JAK1CYP2C19JAK2TYK2JAK3 | |
| SCHEMBL2226057 | 0.82 | JAK1 (0.51) | JAK1CYP2C19JAK2TYK2JAK3 | |
| SCHEMBL2276333 | 0.82 | JAK1 (0.52) | JAK1CYP2C19PKMJAK2TYK2 | |
| SCHEMBL2279026 | 0.82 | JAK1 (0.52) | KMT2AJAK1CYP2C19ALDH1A1JAK2 | |
| SCHEMBL2276300 | 0.81 | JAK1 (0.49) | JAK1CYP2C19PKMJAK2TYK2 | |
| SCHEMBL2280883 | 0.81 | HTT (0.50) | KMT2AMEN1JAK1CYP2C19ALDH1A1 | |
| SCHEMBL2273234 | 0.81 | JAK1 (0.48) | JAK1CYP2C19JAK2TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2523957-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | F. Hoffmann-La Roche AG (CH) | 2012-11-21 | — | — | EP | disclosed |
| WO-2011086053-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2011-07-21 | — | — | WO | disclosed |