Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 11/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2280883 | 0.89 | HTT (0.50) | JAK1SMN1; SMN2HTTMEN1KMT2A | |
| SCHEMBL2276033 | 0.86 | JAK1 (0.53) | JAK1SMN1; SMN2HTTMAOBHTR6 | |
| SCHEMBL2273597 | 0.84 | JAK1 (0.46) | JAK1HTR6 | |
| SCHEMBL2273246 | 0.83 | JAK1 (0.52) | JAK1 | |
| SCHEMBL2269256 | 0.82 | JAK1 (0.46) | JAK1 | |
| SCHEMBL2275305 | 0.82 | JAK1 (0.61) | JAK1MAOBHTR6KMT2A | |
| SCHEMBL13823487 | 0.81 | JAK1 (0.49) | JAK1 | |
| SCHEMBL2223730 | 0.81 | JAK1 (0.53) | JAK1 | |
| SCHEMBL2278824 | 0.81 | JAK1 (0.49) | JAK1HTR6 | |
| SCHEMBL2276041 | 0.80 | JAK1 (0.48) | JAK1SMN1; SMN2HTR6HTR1AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011086053-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2011-07-21 | — | — | WO | disclosed |