Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 19/20 | 0.52 |
| ▸ | JAK2 | O60674 | 13/20 | 0.52 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | PRKCA | P17252 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | TYK2 | P29597 | 2/20 | 0.42 |
| ▸ | JAK3 | P52333 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2280608 | 0.83 | RAF1 (0.46) | JAK1JAK2JAK3 | |
| SCHEMBL27437595 | 0.77 | HTT (0.39) | JAK1JAK2AURKAPRKCAKDR | |
| SCHEMBL2279733 | 0.77 | JAK1 (0.60) | JAK1JAK2JAK3 | |
| SCHEMBL2277347 | 0.75 | JAK1 (0.53) | JAK1JAK2AURKAPRKCAKDR | |
| SCHEMBL12385712 | 0.75 | JAK1 (0.67) | JAK1JAK2AURKAPRKCAKDR | |
| SCHEMBL2279118 | 0.75 | JAK1 (0.69) | JAK1JAK2AURKAPRKCAKDR | |
| SCHEMBL2270472 | 0.74 | JAK1 (0.68) | JAK1JAK2AURKAPRKCAKDR | |
| SCHEMBL2274745 | 0.74 | JAK2 (0.53) | JAK1JAK2AURKAPRKCAKDR | |
| SCHEMBL2276970 | 0.74 | JAK1 (0.50) | JAK1JAK2AURKAPRKCAKDR | |
| SCHEMBL2275380 | 0.73 | JAK1 (0.53) | JAK1JAK2AURKAPRKCAKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011086053-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2011-07-21 | — | — | WO | disclosed |