Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTPS1 | P17812 | 20/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22758486 | 0.90 | CTPS1 (0.45) | CTPS1 | |
| SCHEMBL22758537 | 0.89 | CTPS1 (0.46) | CTPS1 | |
| SCHEMBL22758565 | 0.84 | CTPS1 (0.37) | CTPS1 | |
| SCHEMBL26214529 | 0.84 | CTPS1 (0.41) | CTPS1 | |
| SCHEMBL21392181 | 0.82 | CTPS1 (0.48) | CTPS1 | |
| SCHEMBL21392166 | 0.79 | CTPS1 (0.44) | CTPS1 | |
| Hydrochloric Acid SCHEMBL21384603 | 0.78 | CTPS1 (0.43) | CTPS1 | |
| SCHEMBL22758491 | 0.78 | CTPS1 (0.36) | CTPS1 | |
| SCHEMBL21373839 | 0.76 | CTPS1 (0.49) | CTPS1 | |
| SCHEMBL21387613 | 0.75 | CTPS1 (0.44) | CTPS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020245664-A1 | N-(5-(6-ETHOXYPYRAZIN-2-YL)PYRIDIN-2-YL)-4-(2-(METHYLSULFONAMIDO)PYRIMIDIN-4-YL) TETRAHYDRO-2H-PYRAN-4-CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS HUMAN CTPS1 INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISEASES | STEP PHARMA S.A.S. (FR) | 2020-12-10 | — | — | WO | disclosed |