Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.35 |
| ▸ | CDK2 | P24941 | 2/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 12/20 | 0.34 |
| ▸ | CCR1 | P32246 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | ITK | Q08881 | 1/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.32 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.32 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2277026 | 0.87 | MAPK14 (0.36) | MAPK14CCR1POLBLCKITK | |
| SCHEMBL12373205 | 0.85 | IRAK4 (0.37) | IRAK4CCNA2CDK2MAPK14POLB | |
| Hydrochloric Acid SCHEMBL2273451 | 0.84 | IRAK4 (0.36) | IRAK4CCNA2CDK2MAPK14POLB | |
| SCHEMBL16867249 | 0.80 | IDO1 (0.42) | CCR1POLBLCKITKAURKB | |
| SCHEMBL13962494 | 0.80 | CCR1 (0.37) | CCR1POLBLCKITKAURKB | |
| SCHEMBL2279956 | 0.76 | IRAK4 (0.52) | IRAK4CCNA2CDK2MAPK14MAPK13 | |
| SCHEMBL2275901 | 0.74 | KMT2A (0.40) | IRAK4CCNA2CDK2MAPK14ALDH1A1 | |
| SCHEMBL9254242 | 0.74 | HSD17B10 (0.45) | CCR1ALDH1A1MAPTPKMHSD17B10 | |
| SCHEMBL12401951 | 0.73 | IRAK4 (0.37) | IRAK4CCNA2CDK2MAPK14CCR1 | |
| SCHEMBL2277402 | 0.72 | NPC1 (0.41) | IRAK4CCNA2CDK2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910348-B1 | BENZOTHIAZOLE AND AZABENZOTHIAZOLE COMPOUNDS USEFUL AS KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2016-04-13 | — | — | EP | disclosed |
| EP-1910348-B1 | BENZOTHIAZOLE AND AZABENZOTHIAZOLE COMPOUNDS USEFUL AS KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2016-04-13 | — | — | EP | disclosed |
| US-7994337-B2 | Benzothiazole and azabenzothiazole compounds useful as kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-08-09 | — | — | US | disclosed |
| US-7994337-B2 | Benzothiazole and azabenzothiazole compounds useful as kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-08-09 | — | — | US | disclosed |
| US-7994337-B2 | Benzothiazole and azabenzothiazole compounds useful as kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-08-09 | — | — | US | disclosed |
| EP-2266981-A2 | Benzothiazole compounds useful as kinase inhibitors | Bristol-Myers Squibb Company (US) | 2010-12-29 | — | — | EP | disclosed |
| EP-2266981-A2 | Benzothiazole compounds useful as kinase inhibitors | Bristol-Myers Squibb Company (US) | 2010-12-29 | — | — | EP | disclosed |
| US-20090118272-A1 | BENZOTHIAZOLE AND AZABENZOTHIAZOLE COMPOUNDS USEFUL AS KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY | 2009-05-07 | — | — | US | disclosed |
| US-20090118272-A1 | BENZOTHIAZOLE AND AZABENZOTHIAZOLE COMPOUNDS USEFUL AS KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY | 2009-05-07 | — | — | US | disclosed |
| US-20090118272-A1 | BENZOTHIAZOLE AND AZABENZOTHIAZOLE COMPOUNDS USEFUL AS KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY | 2009-05-07 | — | — | US | disclosed |
| US-7473784-B2 | Benzothiazole and azabenzothiazole compounds useful as kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-01-06 | — | — | US | disclosed |
| US-7473784-B2 | Benzothiazole and azabenzothiazole compounds useful as kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-01-06 | — | — | US | disclosed |
| US-7473784-B2 | Benzothiazole and azabenzothiazole compounds useful as kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-01-06 | — | — | US | disclosed |
| EP-1910348-A2 | BENZOTHIAZOLE AND AZABENZOTHIAZOLE COMPOUNDS USEFUL AS KINASE INHIBITORS | Bristol-Myers Squibb Company (US) | 2008-04-16 | — | — | EP | disclosed |
| US-20070185175-A1 | Benzothiazole and azabenzothiazole compounds useful as kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY | 2007-08-09 | — | — | US | disclosed |
| US-20070185175-A1 | Benzothiazole and azabenzothiazole compounds useful as kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY | 2007-08-09 | — | — | US | disclosed |
| US-20070185175-A1 | Benzothiazole and azabenzothiazole compounds useful as kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY | 2007-08-09 | — | — | US | disclosed |
| WO-2007016392-A2 | BENZOTHIAZOLE AND AZABENZOTHIAZOLE COMPOUNDS USEFUL AS KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-02-08 | — | — | WO | disclosed |
| WO-2007016392-A2 | BENZOTHIAZOLE AND AZABENZOTHIAZOLE COMPOUNDS USEFUL AS KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-02-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090118272-A1 | BENZOTHIAZOLE AND AZABENZOTHIAZOLE COMPOUNDS USEFUL AS KINASE INHIBITORS | GRK2, MAPK9, MAPK1 | IRAK4 610/4885CCNA2 831/4885CDK2 98/4885 |
| US-20070185175-A1 | Benzothiazole and azabenzothiazole compounds useful as kinase inhibitors | GRK2, MAPK1, GRK4 | IRAK4 620/4885CCNA2 840/4885CDK2 95/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.