Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTPS1 | P17812 | 11/20 | 0.44 |
| ▸ | GSK3B | P49841 | 8/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 8/20 | 0.33 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.32 |
| ▸ | CLK2 | P49760 | 2/20 | 0.32 |
| ▸ | CLK3 | P49761 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22758532 | 0.87 | CTPS1 (0.60) | CTPS1 | |
| SCHEMBL22762511 | 0.86 | CTPS1 (0.42) | CTPS1GSK3BDYRK1ACLK2CLK3 | |
| SCHEMBL22762268 | 0.83 | CTPS1 (0.58) | CTPS1 | |
| Hydrochloric Acid SCHEMBL29565805 | 0.82 | CTPS1 (0.58) | CTPS1 | |
| SCHEMBL30528887 | 0.71 | CTPS1 (0.54) | CTPS1 | |
| SCHEMBL22758533 | 0.71 | CTPS1 (0.78) | CTPS1 | |
| SCHEMBL22749234 | 0.71 | CTPS1 (0.54) | CTPS1 | |
| SCHEMBL29565873 | 0.71 | CTPS1 (0.54) | CTPS1 | |
| Hydrochloric Acid SCHEMBL28932323 | 0.70 | CTPS1 (0.77) | CTPS1 | |
| Hydrochloric Acid SCHEMBL29368809 | 0.70 | CTPS1 (0.77) | CTPS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020245665-A1 | N-(4-(5-CHLOROPYRIDIN-3-YL)PHENYL)-2-(2-(CYCLOPROPANESULFONAMIDO)PYRIMIDIN-4-YL) BUTANAMIDE DERIVATIVES AND RELATED COMPOUNDS AS HUMAN CTPS1 INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISEASES | STEP PHARMA S.A.S. (FR) | 2020-12-10 | — | — | WO | disclosed |