Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCQ | Q04759 | 14/20 | 0.83 |
| ▸ | ROCK2 | O75116 | 9/20 | 0.83 |
| ▸ | PRKCA | P17252 | 7/20 | 0.83 |
| ▸ | MAP3K5 | Q99683 | 3/20 | 0.83 |
| ▸ | PRKD3 | O94806 | 7/20 | 0.81 |
| ▸ | PRKCG | P05129 | 7/20 | 0.81 |
| ▸ | PRKCZ | Q05513 | 7/20 | 0.81 |
| ▸ | PRKCB | P05771 | 6/20 | 0.81 |
| ▸ | PRKCH | P24723 | 6/20 | 0.81 |
| ▸ | PRKCI | P41743 | 6/20 | 0.81 |
| ▸ | PRKCE | Q02156 | 6/20 | 0.81 |
| ▸ | PRKCD | Q05655 | 6/20 | 0.81 |
| ▸ | PRKD1 | Q15139 | 6/20 | 0.81 |
| ▸ | EGFR | P00533 | 5/20 | 0.81 |
| ▸ | PRKACA | P17612 | 5/20 | 0.81 |
| ▸ | PRKACG | P22612 | 4/20 | 0.81 |
| ▸ | PRKACB | P22694 | 4/20 | 0.81 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.81 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.81 |
| ▸ | KDR | P35968 | 3/20 | 0.81 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29884772 | 1.00 | PRKCQ (0.83) | PRKCQROCK2PRKCAMAP3K5PRKD3 | |
| SCHEMBL638600 | 1.00 | PRKCQ (0.83) | PRKCQROCK2PRKCAMAP3K5PRKD3 | |
| SCHEMBL260178 | 0.92 | PRKCQ (0.81) | PRKCQROCK2PRKCAMAP3K5PRKD3 | |
| SCHEMBL12253229 | 0.92 | PRKCQ (0.81) | PRKCQROCK2PRKCAMAP3K5PRKD3 | |
| SCHEMBL12253230 | 0.92 | PRKCQ (0.81) | PRKCQROCK2PRKCAMAP3K5PRKD3 | |
| SCHEMBL16437780 | 0.90 | PRKCQ (0.76) | PRKCQROCK2PRKCAMAP3K5PRKD3 | |
| SCHEMBL12570346 | 0.90 | PRKCQ (1.00) | PRKCQROCK2PRKCAMAP3K5PRKD3 | |
| SCHEMBL20841734 | 0.90 | PRKCQ (1.00) | PRKCQROCK2PRKCAMAP3K5PRKD3 | |
| SCHEMBL22765238 | 0.90 | PRKCQ (1.00) | PRKCQROCK2PRKCAMAP3K5PRKD3 | |
| SCHEMBL12570343 | 0.90 | PRKCQ (1.00) | PRKCQROCK2PRKCAMAP3K5PRKD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230002784-A1 | COMPOSITIONS AND METHODS FOR MODIFYING EUKARYOTIC CELLS | ORCHARD THERAPEUTICS (EUROPE) LIMITED (GB) | 2023-01-05 | — | — | US | disclosed |
| WO-2020247814-A1 | COMPOSITIONS AND METHODS FOR MODIFYING EUKARYOTIC CELLS | ORCHARD THERAPEUTICS (EUROPE) LIMITED (GB) | 2020-12-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230002784-A1 | COMPOSITIONS AND METHODS FOR MODIFYING EUKARYOTIC CELLS | PHAX, CD4, POLM | PRKCQ 2458/4885ROCK2 3751/4885PRKCA 2953/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.