Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 8/20 | 0.82 |
| ▸ | EPHA2 | P29317 | 3/20 | 0.82 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.82 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.82 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.82 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.82 |
| ▸ | LMNA | P02545 | 2/20 | 0.82 |
| ▸ | EFNA1 | P20827 | 1/20 | 0.82 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.82 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.82 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.82 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.82 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.82 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.82 |
| ▸ | MEN1 | O00255 | 1/20 | 0.82 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.82 |
| ▸ | CASP7 | P55210 | 3/20 | 0.61 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.61 |
| ▸ | TP53 | P04637 | 2/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25711249 | 1.00 | GPBAR1 (0.82) | GPBAR1EPHA2HSD17B10TDP1AKR1B10 | |
| SCHEMBL18733391 | 1.00 | GPBAR1 (0.82) | GPBAR1EPHA2HSD17B10TDP1AKR1B10 | |
| SCHEMBL25710069 | 1.00 | GPBAR1 (0.82) | GPBAR1EPHA2HSD17B10TDP1AKR1B10 | |
| SCHEMBL13592769 | 1.00 | GPBAR1 (0.82) | GPBAR1EPHA2HSD17B10TDP1AKR1B10 | |
| SCHEMBL19713107 | 1.00 | GPBAR1 (0.82) | GPBAR1EPHA2HSD17B10TDP1AKR1B10 | |
| SCHEMBL4008010 | 1.00 | GPBAR1 (0.82) | GPBAR1EPHA2HSD17B10TDP1AKR1B10 | |
| SCHEMBL28367672 | 0.90 | GPBAR1 (0.77) | GPBAR1EPHA2HSD17B10TDP1AKR1B10 | |
| Ursocholanic Acid SCHEMBL25023044 | 0.90 | GPBAR1 (1.00) | GPBAR1EPHA2HSD17B10TDP1AKR1B10 | |
| SCHEMBL4740095 | 0.90 | GPBAR1 (0.83) | GPBAR1EPHA2HSD17B10TDP1AKR1B10 | |
| Ursocholanic Acid SCHEMBL190519 | 0.90 | GPBAR1 (1.00) | GPBAR1EPHA2HSD17B10TDP1AKR1B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2872161-B1 | DIANHYDROGALACTITOL FOR USE IN TREATING TYROSINE-KINASE-INHIBITOR-RESISTANT MALIGNANCIES IN PATIENTS WITH GENETIC POLYMORPHISMS OR AHI1 DYSREGULATIONS OR MUTATIONS | DEL MAR PHARMACEUTICALS (CA) | 2020-12-16 | — | — | EP | claimed |
| CN-105579044-A | Use of dianhydrogalactitol and analogs and derivatives thereof for treating recurrent malignant glioma or progressive secondary brain tumor | DEL MAR PHARMACEUTICALS | 2016-05-11 | — | — | CN | claimed |
| CN-105579044-A | Use of dianhydrogalactitol and analogs and derivatives thereof for treating recurrent malignant glioma or progressive secondary brain tumor | DEL MAR PHARMACEUTICALS | 2016-05-11 | — | — | CN | disclosed |
| CN-1266192-C | Diamine compound, polyamic acid, imidized polymer, liquid crystal aligning agent and liquid crystal display element | JSR CO LTD (JP) | 2006-07-26 | — | — | CN | disclosed |