Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB1 | Q9H4B7 | 3/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 3/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 3/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.36 |
| ▸ | TUBB | P07437 | 1/20 | 0.36 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29853088 | 1.00 | TUBB1 (0.48) | TUBB1HIF1AESR1ESR2KDM4E | |
| SCHEMBL19422953 | 1.00 | TUBB1 (0.48) | TUBB1HIF1AESR1ESR2KDM4E | |
| SCHEMBL19423035 | 0.95 | TUBB1 (0.47) | TUBB1HIF1AESR1ESR2KDM4E | |
| SCHEMBL22773194 | 0.95 | TUBB1 (0.47) | TUBB1HIF1AESR1ESR2KDM4E | |
| SCHEMBL22773169 | 0.91 | HIF1A (0.39) | TUBB1HIF1AESR1ESR2KDM4E | |
| SCHEMBL29853075 | 0.91 | HIF1A (0.39) | TUBB1HIF1AESR1ESR2KDM4E | |
| SCHEMBL19422940 | 0.91 | PDE4A (0.47) | HIF1AESR1ESR2KDM4EPDE4A | |
| SCHEMBL19422914 | 0.91 | HIF1A (0.39) | TUBB1HIF1AESR1ESR2KDM4E | |
| SCHEMBL22773198 | 0.89 | HIF1A (0.40) | TUBB1HIF1AESR1ESR2KDM4E | |
| SCHEMBL19423029 | 0.89 | PDE4A (0.46) | HIF1AESR1ESR2KDM4EPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200392150-A1 | Diaryl-B-Lactam Compound and Preparation Method and Pharmaceutical Use Thereof | FUDAN UNIVERSITY (CN) | 2020-12-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200392150-A1 | Diaryl-B-Lactam Compound and Preparation Method and Pharmaceutical Use Thereof | PEPD, SQLE, BACE1 | TUBB1 762/4885HIF1A 3899/4885ESR1 4487/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.