Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE2 | O96020 | 5/20 | 0.45 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.45 |
| ▸ | CDK2 | P24941 | 5/20 | 0.45 |
| ▸ | CDK4 | P11802 | 4/20 | 0.45 |
| ▸ | CCND1 | P24385 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | GAPDH | P04406 | 1/20 | 0.44 |
| ▸ | MMP3 | P08254 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22769603 | 0.89 | HDAC2 (0.47) | KDM4EMMP3ALDH1A1GAAHPGD | |
| SCHEMBL22774995 | 0.89 | HDAC1 (0.49) | CDK2MAPTGAAHDAC1HDAC2 | |
| SCHEMBL22784037 | 0.89 | CCNE2 (0.46) | CCNE2CCNE1CDK2CDK4CCND1 | |
| SCHEMBL25143291 | 0.85 | HDAC2 (0.44) | KDM4EMMP3ALDH1A1GAAHPGD | |
| SCHEMBL22769610 | 0.82 | HDAC1 (0.50) | KDM4EALDH1A1GAAHPGDHDAC1 | |
| SCHEMBL22774997 | 0.78 | HDAC1 (0.46) | CDK2KDM4EMAPTKMT2AMEN1 | |
| SCHEMBL22769602 | 0.77 | KDM4E (0.45) | CCNE2CCNE1CDK2CDK4CCND1 | |
| SCHEMBL17279858 | 0.75 | TSHR (0.43) | CCNE2CCNE1CDK2CDK4CCND1 | |
| SCHEMBL1128878 | 0.75 | CA1 (0.47) | CDK2KDM4EMAPTALDH1A1GAA | |
| SCHEMBL25143532 | 0.75 | PDE4A (0.48) | KDM4EMAPTKMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3986868-A1 | HETEROAROMATIC INHIBITORS OF ASTACIN PROTEINASES | Vivoryon Therapeutics N.V. (DE) | 2022-04-27 | — | — | EP | disclosed |
| WO-2020249760-A1 | HETEROAROMATIC INHIBITORS OF ASTACIN PROTEINASES | VIVORYON THERAPEUTICS AG (DE) | 2020-12-17 | — | — | WO | disclosed |