Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 20/20 | 0.65 |
| ▸ | GRIN1 | Q05586 | 19/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22771405 | 0.90 | GRIN2B (0.67) | GRIN2BGRIN1 | |
| SCHEMBL22774681 | 0.89 | GRIN1 (0.65) | GRIN2BGRIN1 | |
| SCHEMBL28936958 | 0.87 | GRIN1 (0.70) | GRIN2BGRIN1 | |
| SCHEMBL22774131 | 0.86 | GRIN1 (0.67) | GRIN2BGRIN1 | |
| SCHEMBL28712195 | 0.85 | GRIN1 (0.68) | GRIN2BGRIN1 | |
| SCHEMBL29604310 | 0.85 | GRIN2B (0.65) | GRIN2BGRIN1 | |
| SCHEMBL22771361 | 0.85 | GRIN2B (0.65) | GRIN2BGRIN1 | |
| SCHEMBL29550162 | 0.84 | GRIN2B (0.71) | GRIN2BGRIN1 | |
| SCHEMBL22775741 | 0.84 | GRIN2B (0.71) | GRIN2BGRIN1 | |
| SCHEMBL22771418 | 0.82 | GRIN1 (0.67) | GRIN2BGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3983073-A1 | SUBSTITUTED PYRAZOLO[4,3-B]PYRIDINES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | Janssen Pharmaceutica NV (BE) | 2022-04-20 | — | — | EP | claimed |
| WO-2020249791-A1 | SUBSTITUTED PYRAZOLO[4,3-b]PYRIDINES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-12-17 | — | — | WO | claimed |
| EP-3983073-A1 | SUBSTITUTED PYRAZOLO[4,3-B]PYRIDINES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | Janssen Pharmaceutica NV (BE) | 2022-04-20 | — | — | EP | disclosed |
| WO-2020249791-A1 | SUBSTITUTED PYRAZOLO[4,3-b]PYRIDINES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-12-17 | — | — | WO | disclosed |