Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.57 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.57 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | FUCA1 | P04066 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | CCR1 | P32246 | 1/20 | 0.43 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15421001 | 1.00 | CHRM2 (0.57) | CHRM2CHRM4CHRM5ALDH1A1FUCA1 | |
| SCHEMBL18508557 | 1.00 | CHRM2 (0.57) | CHRM2CHRM4CHRM5ALDH1A1FUCA1 | |
| SCHEMBL10120550 | 1.00 | CHRM2 (0.57) | CHRM2CHRM4CHRM5ALDH1A1FUCA1 | |
| SCHEMBL10106309 | 1.00 | CHRM2 (0.57) | CHRM2CHRM4CHRM5ALDH1A1FUCA1 | |
| SCHEMBL14213128 | 1.00 | CHRM2 (0.57) | CHRM2CHRM4CHRM5ALDH1A1FUCA1 | |
| SCHEMBL636999 | 0.86 | CHRM2 (0.58) | CHRM2CHRM4CHRM5ALDH1A1FUCA1 | |
| SCHEMBL694189 | 0.84 | CHRM2 (0.62) | CHRM2CHRM4CHRM5ALDH1A1KMT2A | |
| SCHEMBL13993541 | 0.84 | CHRM2 (0.62) | CHRM2CHRM4CHRM5ALDH1A1KMT2A | |
| SCHEMBL16766586 | 0.84 | CHRM2 (0.62) | CHRM2CHRM4CHRM5ALDH1A1KMT2A | |
| SCHEMBL16766562 | 0.84 | CHRM2 (0.62) | CHRM2CHRM4CHRM5ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3983401-A1 | PROGRANULIN MODULATORS AND METHODS OF USING THE SAME | Arkuda Therapeutics (US) | 2022-04-20 | — | — | EP | disclosed |
| WO-2020252222-A1 | PROGRANULIN MODULATORS AND METHODS OF USING THE SAME | ARKUDA THERAPEUTICS (US) | 2020-12-17 | — | — | WO | disclosed |