Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Olcegepant. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALCRL known ✓ | Q16602 | 19/20 | 1.00 |
| ▸ | RAMP1 | O60894 | 8/20 | 1.00 |
| ▸ | CALCA | P06881 | 2/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Olcegepant SCHEMBL3960085 | 1.00 | CALCRL (1.00) | CALCRLRAMP1CALCA | |
| Olcegepant SCHEMBL29357241 | 1.00 | CALCRL (1.00) | CALCRLRAMP1CALCA | |
| Olcegepant SCHEMBL3954313 | 1.00 | CALCRL (1.00) | CALCRLRAMP1CALCA | |
| Olcegepant SCHEMBL2252127 | 1.00 | CALCRL (1.00) | CALCRLRAMP1CALCA | |
| Olcegepant SCHEMBL3959766 | 1.00 | CALCRL (1.00) | CALCRLRAMP1CALCA | |
| Olcegepant SCHEMBL5665838 | 0.99 | CALCRL (0.99) | CALCRLRAMP1CALCA | |
| SCHEMBL14566582 | 0.97 | CALCRL (0.94) | CALCRLRAMP1CALCA | |
| SCHEMBL3960012 | 0.96 | CALCRL (0.92) | CALCRLRAMP1CALCA | |
| SCHEMBL25531342 | 0.95 | CALCRL (0.91) | CALCRLRAMP1CALCA | |
| SCHEMBL14566590 | 0.94 | CALCRL (0.89) | CALCRLRAMP1CALCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240148745-A1 | COMPOUNDS FOR USE IN PROGRESSIVE MULTIPLE SCLEROSIS | FONDAZIONE CENTRO SAN RAFFAELE (IT) | 2024-05-09 | — | — | US | disclosed |
| EP-3870236-B1 | NANOPARTICLE ENCAPSULATION TO TARGET G PROTEIN-COUPLED RECEPTORS IN ENDOSOMES | TAKEDA PHARMACEUTICALS CO (JP) | 2023-08-09 | — | — | EP | disclosed |
| EP-4056231-A1 | COMPOUNDS FOR USE IN PROGRESSIVE MULTIPLE SCLEROSIS | Fondazione Centro San Raffaele (IT) | 2022-09-14 | — | — | EP | disclosed |
| WO-2020252368-A2 | NEW THERAPEUTIC APPROACH TO LUNG DISEASE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2020-12-17 | — | — | WO | disclosed |