Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 2/20 | 0.53 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.53 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.51 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.51 |
| ▸ | ABL1 | P00519 | 1/20 | 0.50 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.50 |
| ▸ | BCR | P11274 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.50 |
| ▸ | RELA | Q04206 | 1/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
| ▸ | VDR | P11473 | 1/20 | 0.47 |
| ▸ | PPARD | Q03181 | 1/20 | 0.47 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | CYP24A1 | Q07973 | 1/20 | 0.47 |
| ▸ | RXRB | P28702 | 1/20 | 0.47 |
| ▸ | RXRG | P48443 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2277479 | 0.89 | F2RL1 (0.67) | F2RL1NFKB1NFKB2RELAHRH3 | |
| SCHEMBL12646450 | 0.87 | MAOB (0.62) | F2RL1HSD17B1HSD17B2VDRPPARD | |
| SCHEMBL5884605 | 0.83 | KMT2A (0.51) | F2RL1HSD17B1HSD17B2NFKB1NFKB2 | |
| SCHEMBL1445627 | 0.83 | F2RL1 (0.73) | F2RL1NFKB1NFKB2RELAALDH1A1 | |
| SCHEMBL12370805 | 0.83 | SYK (0.50) | RXRAHRH3RXRBRXRGPTPN1 | |
| SCHEMBL12370802 | 0.83 | HRH3 (0.50) | RXRAF2RL1HRH3HCAR2RXRB | |
| SCHEMBL2271709 | 0.82 | KMT2A (0.52) | HRH3GAAALDH1A1MEN1KMT2A | |
| SCHEMBL1841217 | 0.81 | HRH3 (0.49) | RXRAF2RL1HRH3HCAR2RXRB | |
| SCHEMBL22922181 | 0.81 | CYP4F2 (0.59) | F2RL1HRH3ALDH1A1POLBKMT2A | |
| SCHEMBL23512353 | 0.80 | HSD17B10 (0.54) | F2RL1HRH3ALDH1A1PTPN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8530689-B2 | Processes for the preparation of biphenyl compounds | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2013-09-10 | — | — | US | disclosed |
| US-8530689-B2 | Processes for the preparation of biphenyl compounds | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2013-09-10 | — | — | US | disclosed |
| US-20110207957-A1 | PROCESSES FOR THE PREPARATION OF BIPHENYL COMPOUNDS | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2011-08-25 | — | — | US | disclosed |
| US-20110207957-A1 | PROCESSES FOR THE PREPARATION OF BIPHENYL COMPOUNDS | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2011-08-25 | — | — | US | disclosed |
| WO-2009137322-A2 | PROCESSES FOR THE PREPARATION OF BIPHENYL COMPOUNDS | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2009-11-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110207957-A1 | PROCESSES FOR THE PREPARATION OF BIPHENYL COMPOUNDS | C1S, BAX, C9 | RXRA 1279/4885F2RL1 1040/4885HSD17B1 2689/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.