Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 9/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.62 |
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.55 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.50 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.50 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.50 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.50 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.50 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.50 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.50 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.50 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.50 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.50 |
| ▸ | KCND3 | Q9UK17 | 1/20 | 0.50 |
| ▸ | ESR1 | P03372 | 1/20 | 0.50 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.50 |
| ▸ | HHAT | Q5VTY9 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30965945 | 1.00 | CHRM3 (0.62) | CHRM3KCNH2TRPM8TRPV1CHRM2 | |
| SCHEMBL7209238 | 1.00 | CHRM3 (0.62) | CHRM3KCNH2TRPM8TRPV1CHRM2 | |
| SCHEMBL29561016 | 1.00 | CHRM3 (0.62) | CHRM3KCNH2TRPM8TRPV1CHRM2 | |
| SCHEMBL7210566 | 0.90 | CHRM3 (0.52) | CHRM3KCNH2TRPM8CHRM2CHRM1 | |
| SCHEMBL12046708 | 0.90 | CHRM3 (0.60) | CHRM3KCNH2TRPV1CHRM2CHRM1 | |
| SCHEMBL1696394 | 0.90 | CHRM3 (0.60) | CHRM3KCNH2TRPV1CHRM2CHRM1 | |
| SCHEMBL13041647 | 0.90 | CHRM3 (0.60) | CHRM3KCNH2TRPV1CHRM2CHRM1 | |
| SCHEMBL1404035 | 0.90 | CHRM3 (0.60) | CHRM3KCNH2TRPV1CHRM2CHRM1 | |
| SCHEMBL28703381 | 0.88 | CHRM3 (0.56) | CHRM3KCNH2TRPM8TRPV1CHRM2 | |
| SCHEMBL7213954 | 0.88 | CHRM3 (0.62) | CHRM3KCNH2TRPM8TRPV1CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230115534-A1 | PROGRANULIN MODULATORS AND METHODS OF USING THE SAME | ARKUDA THERAPEUTICS | 2023-04-13 | — | — | US | disclosed |
| WO-2021127303-A1 | PROGRANULIN MODULATORS AND METHODS OF USING THE SAME | ARKUDA THERAPEUTICS (US) | 2021-06-24 | — | — | WO | disclosed |
| WO-2020252222-A1 | PROGRANULIN MODULATORS AND METHODS OF USING THE SAME | ARKUDA THERAPEUTICS (US) | 2020-12-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230115534-A1 | PROGRANULIN MODULATORS AND METHODS OF USING THE SAME | GRN, PSEN1, PSEN2 | CHRM3 3512/4885KCNH2 4879/4885TRPM8 3953/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.