Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.64 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.63 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.63 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.63 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 3/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | MAPT | P10636 | 3/20 | 0.62 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.62 |
| ▸ | NPC1 | O15118 | 2/20 | 0.61 |
| ▸ | RAB9A | P51151 | 2/20 | 0.61 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.61 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | HPGD | P15428 | 2/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9138101 | 0.85 | HDAC3 (0.71) | NOTUMHDAC3HDAC1HDAC10HDAC11 | |
| SCHEMBL7929895 | 0.84 | HDAC3 (0.70) | NOTUMHDAC3HDAC1HDAC10HDAC11 | |
| SCHEMBL29676811 | 0.84 | NOTUM (0.62) | NOTUMHDAC3HDAC1HDAC10HDAC11 | |
| SCHEMBL30297726 | 0.84 | NPC1 (0.64) | NOTUMHDAC3HDAC1HDAC10HDAC11 | |
| SCHEMBL7299747 | 0.84 | NOTUM (0.62) | NOTUMHDAC3HDAC1HDAC10HDAC11 | |
| SCHEMBL1545565 | 0.84 | NPC1 (0.64) | NOTUMHDAC3HDAC1HDAC10HDAC11 | |
| SCHEMBL303340 | 0.84 | NOTUM (0.67) | NOTUMHDAC3HDAC1HDAC10HDAC11 | |
| SCHEMBL13487186 | 0.84 | NOTUM (0.67) | NOTUMHDAC3HDAC1HDAC10HDAC11 | |
| SCHEMBL5253678 | 0.84 | NOTUM (0.62) | NOTUMHDAC3HDAC1HDAC10HDAC11 | |
| SCHEMBL6228768 | 0.83 | HDAC3 (0.68) | NOTUMHDAC3HDAC1HDAC10HDAC11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020252222-A1 | PROGRANULIN MODULATORS AND METHODS OF USING THE SAME | ARKUDA THERAPEUTICS (US) | 2020-12-17 | — | — | WO | disclosed |