Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRCP | P42785 | 4/20 | 0.59 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.39 |
| ▸ | GID4 | Q8IVV7 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29561967 | 1.00 | PRCP (0.59) | PRCPRECQLGAAKDM1AMAPT | |
| SCHEMBL4061572 | 1.00 | PRCP (0.59) | PRCPRECQLGAAKDM1AMAPT | |
| SCHEMBL21063709 | 0.85 | PRCP (0.59) | PRCPRECQLGAAKDM1ARAB9A | |
| SCHEMBL3956419 | 0.84 | KDM1A (0.51) | PRCPRECQLGAAKDM1ARAB9A | |
| SCHEMBL4064540 | 0.84 | KDM1A (0.51) | PRCPRECQLGAAKDM1ARAB9A | |
| SCHEMBL3956423 | 0.84 | KDM1A (0.51) | PRCPRECQLGAAKDM1ARAB9A | |
| SCHEMBL4062159 | 0.84 | PRCP (0.47) | PRCPRECQLGAAKDM1ARAB9A | |
| SCHEMBL21063720 | 0.74 | PRCP (1.00) | PRCPRECQLGAAKDM1AMAPT | |
| SCHEMBL21095884 | 0.74 | PRCP (1.00) | PRCPRECQLGAAKDM1AMAPT | |
| SCHEMBL6084553 | 0.74 | PRCP (1.00) | PRCPRECQLGAAKDM1AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020252222-A1 | PROGRANULIN MODULATORS AND METHODS OF USING THE SAME | ARKUDA THERAPEUTICS (US) | 2020-12-17 | — | — | WO | disclosed |