⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26921985 | 0.83 | USP2 (0.41) | — | |
| SCHEMBL23564070 | 0.80 | USP2 (0.33) | — | |
| SCHEMBL158419 | 0.78 | USP2 (0.41) | — | |
| SCHEMBL8461432 | 0.78 | — | — | |
| SCHEMBL13864364 | 0.77 | — | — | |
| SCHEMBL16985068 | 0.75 | USP2 (0.31) | — | |
| SCHEMBL14858759 | 0.74 | KMT2A (0.31) | — | |
| SCHEMBL14858098 | 0.74 | KMT2A (0.31) | — | |
| SCHEMBL14858592 | 0.74 | KMT2A (0.31) | — | |
| SCHEMBL14129059 | 0.73 | KDM4E (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020252222-A1 | PROGRANULIN MODULATORS AND METHODS OF USING THE SAME | ARKUDA THERAPEUTICS (US) | 2020-12-17 | — | — | WO | disclosed |